Books  Animal & General Biology  Biochemistry & Molecular Biology 

Structure and Dynamics of Biomolecules

By: Erik Geissler, Eric Fanchon, Jean-Louis Hodeau, Jean-Rene Regnard and P Timmins

304 pages, Figs

Oxford University Press

Paperback | Feb 2000 | #107220 | ISBN: 0198504527
Availability: Usually dispatched within 2-3 weeks Details
NHBS Price: £84.99 $104/€95 approx
Hardback | Dec 2000 | #107219 | ISBN: 0198504535
Out of Print Details

About this book

HERCULES is a course on the underlying principles and methods of neutron and synchrotron radiation techniques used in scientific research, constructed around laboratory practicals, tutorials and lectures and designed for biologists, chemists, geologists and physicists. This volume, the fourth in the HERCULES series, is the basis of the lecture course describing the theory and practice of techniques using either thermal neutrons or X- rays from a synchrotron source applied to the modern problems of biology. The themes treated are the crystallographic determination of protein structure, protein dynamics and partially ordered systems. A fourth section on more specialized topics includes spectroscopic techniques, X-ray microscopy, neutron spin polarization contrast methods and investigations of more complex molecules. Each chapter describes a different aspect of the subject, and the contributors are international authorities in their field. The book will be of use not only to beginners, but also, owing to the breadth of its scope, for experienced practitioners.


Foreword; Introduction; Challenges in structural molecular biology: genomics in three dimensions; Data collection and reduction methods; Experimental phase determination of structure factors phases in biocrystallography; Electron density - calculation, modification and interpretation; Neutron crystallography of biological molecules; Reactions in crystals and time-resolved crystallography; Local structure of metalloproteins at atomic resolution by XAFS; Molecular dynamics; Inelastic and Quasielastic neutron scattering: complementarity with biomolecular simulation; Diffuse X-ray scattering from molecular crystals; Small-angle X-ray scattering by solutions of biological macromolecules; Small angle neutron scattering; Structure, dynamic and function of the proton pump bacteriorhodopsin; Fibre and muscle diffraction; Biological spectroscopy using low energy (VUV/UV) synchrotron radiation; X-ray microscopy; Crystallography of viruses and very large macromolecules; The quest for high resolution phasing for large macromolecular assemblies exhibiting severe non-isomorphism, extreme beam sensitivity and no internal symmetry; Nuclear spin contrast variation studies on macromolecular complexes

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