Provides an introduction to the concepts and techniques of recombinant DNA research and their dramatic results. This book explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the experiments that redefined our understanding of DNA.
'This book is a very welcome and updated 3rd edition of the text that was originally published in 1981...The book puts the breathtaking progress made in this field into historical context and is written in a very clear and concise manner with numerous colour illustrations to aid the reader's understanding...I cannot recommend this book more highly!'. - Christopher Ring, Society for General Microbiology
Foundations of DNA - Overview - DNA is the Primary Genetic Material - From DNA to Protein - Basics of Gene Expression - Basic Tools of Recombinant DNA - Fundamental Features of Genes - Getting DNA into Cells and Organisms - Moveable Elements - Epigenetics - RNAi - Foundations of Genomics - Overview - Sequencing a Small Genome - How the Human Genome was Sequenced - Analyzing Genomes - Overview - Sequence Analysis - Genome-wide Functional Analysis - Genomic Approaches to Human Biology - Hunting Human Disease Genes - Cancer Genomics - DNA and Justice
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JAMES D. WATSON is the Chancellor of Cold Spring Harbor Laboratory, USA, and was awarded the Nobel Prize (1962) for his discoveries concerning the molecular structure of nucleic acids. AMY A. CAUDY is a Lewis-Steiger Fellow, at the Lewis-Steiger Institute for Integrative Genomics at Princeton University, USA. Combining methods from genomics, and biochemistry, her research seeks to understand the regulation of mitochondrial replication and abundance. RICHARD M. MYERS is the Stanford W. Ascherman Professor and Chairman of the Department of Genetics at Stanford University, USA. He studies the structure, function and evolution of the human genome to understand roles that genes play in human diseases such as Huntington disease, Parkinson disease, hypertension, insulin resistance, and atherosclerosis. JAN A. WITKOWSKI is the Executive Director of the Banbury Center, USA, the Editor-in-chief of Trends in Biochemical Sciences and a professor at the Watson School of Biological Sciences. Prior to his role at Cold Spring Harbor, he ran a research lab focused on the DNA-based diagnosis of human genetic diseases.