H. Marquardt and S. Schafer, Foreword. Fundamentals: D. Milles, History of Toxicology. L. Hothorn and G. Hajian, Biostatistics in Toxicology. B. Fichtl, Toxicokinetics. F. Oesch and M. Arand, Xenobiotic Metabolism. M. Younes, Free Radicals and Reactive Oxygen Species. D. Brusick, Genetic Toxicology. H. Marquardt, Chemical Carcinogenesis. R. Schulte-Hermann, B. Marian, and W. Bursch, Tumor Promotion. K. Tindall and R. Tennant, Transgenic Rodent Models. J.-A. Gustafsson and C. Corton, Receptor Biology and Pathobiology. D. Polka, Mechanisms of Toxicity: Programmed Cell Death (Apoptosis). J.P. Groton, P.J. van Bladeren, F.R. Cassee, C. De Rosa, and V. Feron, Mixtures. Organtoxicity: R. Kahl, The Liver. C. Cojocel and E. Lock, The Kidney. H. Muhle and R. McClellan, Respiratory Tract. P. Eyer and R. Klimmek, Blood and Blood Forming Organs. D. Neubert, Immune System. J. Riviere and N. Montiero-Riviere, Skin Toxicology. R. Pfeiffer, Eye. D. Ray and K. Andreas, Nervous System. D. Neubert and F. Welsch, Reproduction and Development. J. Thomas and M. Thomas, Endocrine System-Adrenal Cortex Thyroid and Pancreas. K. Schumann, B. Elsenhans, and E. Richter, Gastrointestinal Tract. P. Boor, Cardiovascular Toxicology. Toxicology of Compounds: G. Koss and I. Tesseraux, Hydrocarbons. H. Bolt and J. Borlak, Halogenated Hydrocarbons. S. Magda, Flurohydrocarbons. E. Rose, E. Hodgson, and M. Roe, Pesticides. G. Koss and D. Wolfe, Dioxin and Dioxin-like Polychlorinated Hydrocarbons and Biphenyls. E. Richter and G. Sabbioni, Aromatic Amines, Nitroarenes and Heterocyclic Aromatic Amines. W. Kohl and G. Eisenbrand, N-Nitroso Compounds. S. Schaferwq, B. Elsenhans, R.L.F. Dawes, K. Schumann, and W. Forth, Metals. P. Eyer, Gases. D. Warheit, T. Hesterberg, and G. Hart, Fiber Toxicology. L. Szinicz and S. Baskin, Chemical and Biological Agents. D. Hoffmann and E. Wynder, Active and Passive Smoking. J. Corbett, W. Dressler, and R. Sharma, Cosmetics. E. Loser and G. Stropp, Polymers. U. Hagen, R.J. Preston, R. Fry, and J. Kummermehr, Radiation. J. Westendorf, The Toxicology of Natural Compounds. H. Bigalke and H. Wellhoner, Bacterial Toxins. Application of Toxicology: H.W. Rudiger, Biomonitoring and Occupational Medicine. Environmental Toxicology: R. Bull, Water. D.J. Paustenbach and T. Rodrigues, The Role of Toxicology and Risk Assessment in Environmental Remediation. Krekeler, Ecotoxicology. Hattan and A. Rulis, Food Toxicology. Gelbke, B. Hildebrand, and E. Kerfoot, Toxicological Evaluation Methods for the Registration of Chemicals. H. Spielmann, Alternatives in Toxicological Testing. A. Somogyi, Regulatory Toxicology. Risk Assessment: D. Neubert and R. Conolly, Possibilities and Methods of Quantitative Risk Assessment. S. Safe, Toxicity Equivalents and Their Use in Hazard and Risk Assessment. Appendix: I. Ollroge, Threshold Values and Recommendations. H. Marquardt and S. Schafer, Addresses of Toxicology Center and Information Sources.