772 pages, colour illustrations, colour tables
Provides a definitive guide to this vibrant and evolving discipline. Understanding Bioinformatics takes a conceptual approach. It guides the reader from first principles through to an understanding of the computational techniques and the key algorithms.
Understanding Bioinformatics is divided into seven sections, with the opening section introducing the basics of nucleic acids, proteins and databases. Subsequent sections are divided into 'applications' and 'theory' chapters, allowing readers to focus their attention effectively. In each section, the applications chapter provides a fast and straightforward route to understanding the main concepts and 'getting started'. Each of these is then followed by theory chapters which give greater detail and present the underlying mathematics. In section two, Sequence Alignments, the applications chapter shows the reader how to get started on producing and analyzing sequence alignments, and using sequences for database searching, while the next two chapters look closely at the more advanced techniques and the mathematical algorithms involved. Section three covers evolutionary processes and shows how bioinformatics can be used to help build phylogenetic trees. Section four looks at the characteristics of whole genomes. In Sections five and six the focus turns to secondary and tertiary structure – predicting structural conformation and analysing structure-function relationships. The last section surveys methods of analyzing data from a set of genes or proteins of an organism and is rounded off with an overview of systems biology.
'Congratulations on a fine book! I do not think I have seen such a comprehensive text on bioinformatics algorithms and techniques before. I think this will be an invaluable resource for the bioinformatics community and researchers of neighbouring disciplines.' "-" "Jaap Heringa, Free University, Amsterdam" 'This is very well done. Compared to other competing textbooks, your book will be probably the first one that explains gene finding in detail.' "- Sun Kim, Indiana University, Bloomington, USA"
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Marketa Zvelebil is the team leader of cancer informatics at The Breakthrough Toby Robins Breast Cancer Research Centre. Jeremy O. Baum is an Honorary Teaching Fellow in the School of Crystallography, Birkbeck College.