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Advanced Genetic Analysis explores the question "How can the principles of genetics be used as analytical tools to solve biological problems?" Drawing on the latest experimental tools, including microarrays, RNAi, and bioinformatics approaches, it provides a state-of-the-art review of the field, but in a truly student-friendly manner.
UNIT 1 GENES AND GENOMES; 1. The logic of genetic analysis; 2. Model organisms and their genomes; UNIT 2 GENES AND MUTANTS; 3. Identifying mutants; 4. Classifying mutants; 5. Connecting a phenotype to a DNA sequence; 6. Finding mutant phenotypes for cloned genes; 7. Genome-wide mutant screens; UNIT 3. GENE ACTIVITY; 8. Molecular analysis of gene expression; 9. Analysis of gene activity using mutants; UNIT 4. GENE INTERACTIONS; 10. Using one gene to find more genes; 11. Epistasis and genetic pathways; 12. Pathways, networks, and systems
'It is refreshing to see the focus move away from the detail of molecular mechanism towards understanding and scientific investigation' The Society for General Microbiology 'Philip Meneely makes a concerted effort to tie the key concepts derived from model systems to an understanding of human medical genetics, which works well and will be appreciated by students.' The Society for General Microbiolo gy I enjoyed reading this chapter with its wonderful analogies...The author is gifted in writing in such a way that the reader will understand difficult concepts. Helena Kuivaniemi, Center for Molecular Medicine and Genetics, Wayne State University, USA