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This book constitutes the refereed proceedings of the 4th Brazilian Symposium on Bioinformatics, BSB 2009, held in Porto Alegre, Brazil, in July 2009.
The 12 revised full papers and 6 extended abstracts were carefully reviewed and selected from 55 submissions. The papers are organized in topical sections on algorithmic approaches for molecular biology problems; micro-array analysis; machine learning methods for classification; and in silico simulation.