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Apoptosis: The Molecular Biology of Programmed Cell Death

Edited By: Michael Jacobson, Nicola Mccarthy and Nicola McCarthy

346 pages, illus

Oxford University Press

Paperback | Apr 2002 | #178593 | ISBN: 0199638497
Availability: Usually dispatched within 5 days Details
NHBS Price: £65.00 $86/€74 approx

About this book

Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity to apoptotic triggers can cause cells to be lost inappropriately from tissues, as appears to occur in neurodegenerative diseases. This book examines the molecular pathways regulating apoptosis, progressing from the nematode worm through Drosphila to the more complex pathways evident in mammalian cells. Differences in the cell death pathway within specific tissues are addressed, as are the different genes that may act to regulate progressive steps.

The book is, essentially, a series of reviews of a quality you would expect to find in the top scientific journals. Not only will it prove a good introduction to researchers new to the field, it provides a very useful reference guide to those of us who are not specialists in PCD, but upon whose work the subject often impinges. Journal of Biological Education All the subjects are addressed at just the right level of complexity, with the emphasis on molecular processes involved ... four excellent colour plates. Journal of Biological Education


1. Why be interested in death?; 2. Programmed cell death in C.elegans: the genetic framework; 3. Genetic and molecular analysis of programmed cell death in Drosophila; 4. The caspases: from here to eternity; 5. Regulation of apoptosis by the Bcl-2 family of proteins; 6. Mitochondria in apoptosis: Pandora's Box; 7. Apoptosis: lessons from free cell systems; 8. Death signalling by the CD95/TNFR family of death domain containing receptors; 9. Survival signalling by phosphorylation: PI3K/Akt sets the stage; 10. Viruses and apoptosis; 11. Cell death in the nervous system

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