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Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.
Nucleosome and Chromatin Structure; DNA Replication, Nucleotide Excision Repair and Nucleosome Assembly; Chromatin Structure and Control of Transcription in Vivo; The Genetics of Chromatin Function; The SWI/SNF family of remodeling complexes; ATP-Dependent Chromatin Remodeling and Assembly by the ISWI Complexes; Histone Acetyltransferase/Transcription Coactivator Complexes; Histone Deacetylation: mechanisms of repression; Developmental Regulation of Chromatin Function and Gene Expression; Chromatin Contributions to Epigenetic Transcriptional States in Yeast; Epigenetic Regulation in Drosophila: unraveling the conspiracy of silence; Epigenetics in Mammals; Chromatin Boundaries; Linking Large-Scale Chromatin Structure with Nuclear Function