By: TA Brown
572 pages, illustrations, maps, tables
Fuses the fresh outlook of the new genomics with the traditional approach to gene expression to provide an up-to-date understanding of the role of the genome as the blueprint for life.
...a broad appeal to all levels of biology undergraduates, even the more zoology inclined, who these days will be unable to avoid learning about molecules. However, even they will be happy with the substantial chapters on evolution, which is afforded considerably! The Times Higher Education
Part 1. Studying Genomes. 1. Genomes, Transcriptomes and Proteomes (this is the floating chapter). 2. Studying DNA. 3. Mapping Genomes. 4. Sequencing Genomes. 5. Understanding a Genome Sequence. 6. Understanding How a Genome Functions Part 2. Genome Anatomies. 7. Eukaryotic Nuclear Genomes. 8. Genomes of Prokaryotes and Eukaryotic Organelles. 9. Virus Genomes and Mobile Genetic Elements. Part 3. How Genomes Function. 10. Accessing the Genome. 11. Assembly of the Transcription Initiation Complex. 12. Synthesis and Processing of RNA. 13. Synthesis and Processing of the Proteome. 14. Regulation of Genome Activity Part 4. How Genomes Replicate and Evolve. 15. Genome Replication. 16. Mutations and DNA Repair. 17. Recombination. 18. How Genomes Evolve. 19. Molecular Phylogenetics
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Professor Terry Brown graduated from Queen Elizabeth College, London with a BSc Hons in Microbiology in 1974, and from University College London with a PhD in 1977. He joined the University of Manchester Institute of Science and Technology as a postdoctoral researcher in 1981, and has remained in Manchester ever since, becoming the UK's first Professor of Biomolecular Archaeology in 2000. He was Head of Biomolecular Sciences from 2002 - 2004 and has been Associate Dean in Life Sciences since 2004. Terry Brown has been active in genomics and biomolecular archaeology since 1989. He is particularly interested in the origins and spread of agriculture and has published a number of research papers that describe how examination of the genomes of wheat and maize can provide information on the history of cultivation of these crops.
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