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Handbook of Biotransformations of Aromatic Compounds

By: BL Goodwin


Hardback | Dec 2004 | #147119 | ISBN: 0415271762
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NHBS Price: £344.00 $451/€392 approx

About this book

Understanding the biotransformations of aromatic compounds and how they metabolize in animals, plants, and microbes, is central to the applications in a wide range of industries, such as the design and testing of natural and synthetic pharmaceuticals, oil refining, the development of agrochemicals, bioremediation, and for use in functional genomics and xenobiotics. Presenting the most complete resource of its kind, the Handbook of Biotransformations of Aromatic Compounds examines 20,000 aromatic compounds researched since 1972, and assembled from all the major, relevant journals. The author focuses his coverage on the biotransformation in animals, plants, and microbes while remaining within the scope of aromatic compounds that contain, or are fused with, at least one aromatic C6 ring. Part One lists each compound alphabetically along with the forward and reverse mechanisms of its metabolism in specific organisms. Part Two characterizes the different types of organic reactions that have been identified - including formation and degradation, oxidations and reductions, substitution, and transfer reactions - and the enzymes associated with those reactions. The author cites selected references for enzymes that are well documented while filling in the details for those with little research literature. This book also contains a searchable CD-ROM of the author's previous work covering aromatic compounds researched from 1900 through 1972.Presenting the most complete resource of its kind, this well-established author draws on his firsthand knowledge to organize a large body of information into a user-friendly and indispensable handbook for professionals, policymakers, and researchers alike.


PART 1Alphabetical Listing of Aromatic CompoundsPART 2REACTIONS INVOLVING THE FORMATION AND DEGRADATION OF THE AROMATIC NUCLEUSAromatization of 6-membered carbon and heterocyclic ringsFormation of carbon ring systemsFormation of heterocyclic ring systemsPolymerization reactionsReactions involving carbon ring fissionReactions involving heterocyclic ring fissionDearomatizationRing expansionOXIDATIONS AND REDUCTIONS INVOLVING THE AROMATIC NUCLEUS AND NON-ORGANIC SUBSTITUENTSHydroxylation of the aromatic nucleusFormation of quinones and analogues from catechols, quinols and other precursorsFree radicals from phenolsOxidation of nuclear amino groups and analoguesOxidation of heterocyclic aminesReduction of nitro groups and analoguesOxidation and reduction of sulphur atomsReduction of quinones and analoguesHalogens and the aromatic nucleusEpoxide formation and reductionDeamination of arylamines without hydroxylationDehydroxylation of phenolsNitro group addition and removalOXIDATIONS AND REDUCTIONS OF SUBSTITUENT SIDE CHAINS AND NON-AROMATIC RING SYSTEMS (WITHOUT ALTERING CHAIN LENGTH)Hydroxylation of the carbon side-chainAlkyl oxidation to ketoneOxidations and reductions of alcohols, aldehydes and ketonesReductions of acidsDeaminationOxidative removal of substituents on amino groupsOxidations and reductions involving nitrogen atomsO-DealkylationOxidations and reductions of non-aromatic ring systemsSulphur replacementDehydroxylationSide chain halogenationOxidative rearrangementFORMATION AND DEGRADATION OF SIDE-CHAINSSide-Chain FormationDecarboxylation of phenolic groups without hydroxylationDecarboxylation reactions of side-chainsOther reactions involving side-chain shortening and removalChain lengthening reactionsCONJUGATION AND SUBSTITUTION REACTIONSEster formationSulphamate formationGlycoside formationConjugation of thiolsFormation of amides and substituted amidesPhosphorylation reactionsEther formationN-alkylationSilane anhydridesELIMINATION OF SUBSTITUENTSEster hydrolysisHydrolysis of glycosidesHydrolysis of amidesHydrolysis of phosphatesMiscellaneous reactionsTRANSFER REACTIONSTransaminationIsomerizationMigrationsRacemizationFORMATION AND REACTIONS OF NON-ARYL DOUBLE AND TRIPLE BONDSDouble and triple bond formationReactions of double bondsHYDRATION OF EPOXIDESLIGHT-FORMING REACTIONSINDEXBIBLIOGRAPHY

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