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At long last, the mechanism-based and application-oriented handbook of combinatorial chemistry. Since its very beginning, research in this field has continued to develop at a rapid rate. Increasingly elegant methods are being invented and an even wider range of possible applications is still being discovered, such that combinatorial chemistry is now an integral part of industrial and academic research. The high-class editorial team - K. C. Nicolaou of The Scripps Institute and UCSD, and R. Hanko and W. Hartwig from Bayer - ensure comprehensive coverage and top quality contributions. This two-volume work deals with synthetic chemistry in all its forms, applications from life sciences, chemistry and material sciences, all there is to know about compound library design and synthesis, and, of course, the general basics - making it an indispensable reference for synthetic, organic and medicinal chemists, chemical biologists as well as material scientists.
VOLUME 1. PART I: GENERAL ASPECTS Combinatorial Chemistry in Perspective (K.C. Nicolaou, et al.). Introduction to Combinatorial Chemistry (David L. Coffen and Joachrim E.A. Luithle). Solid Phase and Soluble Polymers for Combinatorial Synthesis (Rainer Haag, et al.). Linkers for Solid--phase Synthesis (Stefan Base and Stefan Dahmen). Encoding Technologies (Thomas Kramer, et al.). Instrumentation for Combinatorial Chemistry (Marcus Bauser and Hubertus Stakemeier). PART II: SYNTHETIC CHEMISTRY. radical Reactions in Combinatorial Chemistry (A. Ganesan and Mukund P. Sibi). Nucleophilic Substitution in Combinatorial and Solid--phase Synthesis (Jan--Gerd Hansel and Stephan Jordan). Electrophillic Substitution in Combinatorial and Solid--phase Synthesis (Jan--Gerd Hansel and Stephan Jordan). Elimination Chemistry in the Solution-- and Solid--phase Synthesis of Combinatorial Libraries (Demosthenes Fokas and Carmen Baidino). Addition to CC Multiple Bonds (Except for CC Bond Formation) (Adiran L. Smith). Addition to Carbon--Hetero Multiple Bonds (Philipp Grosche, et al.). Chemistry of the Carbonyl Group (Tobias Wunberg). Oxidation Except CC Double Bonds (Henning Steinhagen). Reductions in Combinatorial Synthesis (Christopher P. Corrette and Conrad W. Hummel). Cycloadditions in Combinatorial and Solid--phase Synthesis (Markus Albers and Thorsten Meyer). Msin Group Organometallics(Christopher Kallus). Enolates and Related Species in Combinatorial and Solid--phase Synthesis (Jochen Kruger). Solid--phase Palladium Catalysis for High--throughput Organic Synthesis (Yasuhiro Uozumi and Tamio Hayashi). Olefin Metathesis and Related Processes for CC Multiple Bond Formation (Florencio Zaragoza). VOLUME II. PART III: SPECIAL SYNTHETIC TOPICS. Solid--phase Synthesis of Natural Products and Natural Product--like Libraries (K.C. Nicolaou and Jeffrey A. Pfefferkorn). Solid--phase Synthesis of Heterocyclic Systems (Heterocycles Containing One Heteroatom) (Roland E. Dolle). Multicomponent Reactions (Arounarith Tuch and Stefac Walle). Strategies for Creating the Diversity of Oligosacchrides (Pamela Sears and Chi--Huey Wong). PART IV: MOLECULAR DESIGN AND COMBINATORIAL COMPOUND LIBRARIES. Desiagn Criteria (Josef Pernerstorfer). Estimation of Physiochemical and ADME Parameters (Michael W. Harter, et al.). Virtual Compound Libraries and Molecular Modeling (Roger M. Brunne, et al.). Erythropoietin Sensitzer -- A Case Study (Berthold Hinzen, et al.). Estimation of Stability and Shelf Life of Compounds, Libraries, and Repositories in Combination with Systematic Discovery of New Rearrangement Pathways (Ference Darvas, et al.). PART V: NOVEL APPLICATIONS OF COMBINATORIAL CHEMISTRY. Concepts of Combinatorial Chemistry in Process Development (Markus Eckert and Ulrich Notheis). High--throughput Screening Applied to Process Development (Oliver Brummer, et al.). Combinatorial Methods in Catalysis (Bill Archibald, et al.). Diversity--Based Identification of Efficient Homochiral Organometallic Catalysis for Enantioselective Synthesis (Amir H. Hoveyda). Combinatorial Aspects of Material Science (Bill Archibald, et al.). Reprogramming Combinatorial Biology for Combinatorial Chemistry (Sean V. Taylor). Index.
...an up--to--date, authoritative, comprehensive reference source that should be indispensable for synthetic, organic and medicinal chemists; chemical biologists; and material scientists. (The Chemical Educator, Vol. 10, No. 4. 2005) "...an excellent contribution to the field of research..." (Chemistry & Industry, 6 January 2003) "...this book is a valuable and rich source of information..." (Perkin Transactions, Vol.1, No.23, 2002) "...it is an excellent reference book that most researchers in the field will want on their bookshelves and/or in their library..." (Synthesis, No. 7, 2003)