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A Unique Collection of High-Quality Articles - Derived from the Acclaimed Encyclopedia of Life Sciences.
The Handbook of Human Molecular Evolution comprises nearly 300 articles written by experts in human molecular evolution for a specialist audience. The book introduces the reader to all aspects of the study of evolutionary processes at the DNA, RNA, chromosome and protein level. Coverage spans from the basic principles of mutation, adaptation and natural selection to the evolution of the human genome, gene structure and function. Separate sections are devoted to population genetics and the evolution of disease susceptibility. While much research in genetics has been conducted using model organisms, this book focuses on human evolution, addressing those fascinating questions: Who are we and Where have we come from?
Key topics include the evolution of enzyme function, the use of nucleic acid divergence as a "molecular clock", the origin of non-functional or junk DNA, the role of gene duplication in the emergence of novel gene function and the identification of molecular changes responsible for various human characteristics especially those pertaining to infection, cognition, disease and disease susceptibility.
This essential reference work consists of self-contained, peer-reviewed articles written by leading scientists in each field. It features introductory articles aimed at undergraduates and non-specialists, which provide basic information and a list of recommended further reading to encourage the reader to explore a topic in more depth. This approach helps the student reader progress from textbook material to primary literature. The introductory articles are complemented by advanced articles, written for postgraduate students and research workers, which contain more detailed information and key references allowing the reader to investigate a specific area in more depth. This format allows professionals to use the books as a quick reference source.
The articles are thematically arranged in 12 major sections, covering the whole scope of research into human molecular evolution.
This splendid compendium... will be the standard reference work for years to come: a handbook to browse, to consult, to look things up in, and to read with pleasure, wonder and post-Darwinian exhilaration. (Richard Dawkins) "This is a marvellous book ... For many years to come, these two volumes will be the starting point for anyone wishing to find out about virtually any subject relating to human genetics." (Human Genetics) "The publishers and editors deserve to be congratulated for publishing this major book which coincides with the 200th anniversary of the birth of Charles Darwin." (Genomic Medicine)