Handbook of Systems Biology Concepts and Insights

About this book

Handbook of Systems Biology provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. Handbook of Systems Biology: emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines; includes the latest research developments in human and animal models to assist with translational research; and, presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers.

Contents

SECTION I: Component of biological systems
Proteomic analysis of cellular systems
The protein-coding transcriptome
ncRNAs and their targets

SECTION II: Network properties of biological systems
Probabilistic functional networks
Protein-protein inteactome networks
Gene regulatory networks
Phenotypic profiling networks
Genetic interaction networks
Chromatin networks
Drug-target networks
Graph theory properties of cellular networks

SECTION III: Dynamic and logical propoerties of biological systems
Boolean models of cellular networks
Bayesian approaches in understanding networks
Transcriptional network logic in development
Metabolic systems reconstruction
Evolution of biological networks
Systems understanding of the cell cycle
Quantitative design principles on molecular systems
Systems biology of signaling
Single cell systems dynamics
Spatial organization of cellular systems

SECTION IV: Systems and biology
Systems understanding of yeast biology
systems understandingof c.elegans development
Biological systems in Arabidopsis
Biological rhythms in development and hemeostasis
System biology of stem cells
The brain connectome

SECTION V:MULTISCALE BIOLOGICAL SYSTEMS, HEALTH AND ECOLOGY
Systems medicine
Cancer systems biology
Infectious disease and the immune system
Network perturbations and disease states
Impact of personal genomics on systems biology
Social networks, human disease, and epidemics

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