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Academic & Professional Books  Organismal to Molecular Biology  Biochemistry & Molecular Biology

Introduction to Protein Architecture: The Structural Biology of Proteins

Out of Print
By: A Lesk
347 pages, Col plates, illus, figs, tabs
Introduction to Protein Architecture: The Structural Biology of Proteins
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  • Introduction to Protein Architecture: The Structural Biology of Proteins ISBN: 9780198504740 Paperback Sep 2000 Out of Print #118412
About this book Contents Related titles

About this book

Explains the general characteristics that underlie the very great variety of structures, functions and interactions of proteins observed in nature.

Contents

CHAPTER 1: THE PHOTOSYNTHETIC REACTION CENTRE: PROTEIN STRUCTURE IN A MICROCOSM; The reaction centre from Rhodopseudomonas viridis; Conclusions; Recommended reading and references; Exercises and problems; CHAPTER 2: IN VIVO, IN VITRO, IN SILICO; Why study proteins?; Protein structure and conformation; The known protein sequences; The protein data bank; The World-Wide Web; Summary; Glossary; Useful Web sites; Recommended reading and references; Exercises, problems and weblems; CHAPTER 3: PATTERN AND FORM IN PROTEIN STRUCTURE; Helices and sheets; The heirarchical nature of protein architecture; An album of small structures; Classification of protein structures; Loops; Protein-ligand interactions; Useful Web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 4: THE VARIETIES OF PROTEIN STRUCTURE; Catalogues of protein structure; The known structures; alpha-helical proteins; beta-sheet proteins; alpha + beta proteins; alpha/beta proteins; Closed beta-alpha-beta barrel structures; Irregular structures; Conclusions; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 5: MOLECULAR EVOLUTION; Evolution of protein structures; Structural relationships among related molecules; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 6: EVOLUTION IN SELECTED PROTEIN FAMILIES; Evolution of the globins; Evolution of serine proteinases of the chymotrypsin family; NAD-binding domains of dehydrogenases; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 7: SOME PROTEINS OF THE IMMMUNE SYSTEM; Antibody structure; Proteins of the Major Histocompatibility Complex; T cell receptors; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 8: CONFORMATIONAL CHANGES IN PROTEINS; Structural changes arising from change in state of ligation; Hinge motions in proteins; The helix interface shear mechanism of conformational change; The allosteric change in haemoglobin; Serpins: SERine Proteinase Inhibitors; Higher-level structural changes; INDEX

Customer Reviews

Out of Print
By: A Lesk
347 pages, Col plates, illus, figs, tabs
Media reviews
This is truly a monument to the architecture of proteins: a gorgeous tour of the structures that dwell within us. The "frozen music" of biology is clearly presented in beautiful detail. The text should be considered for any introductory graduate level course in biochemistry.
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