Investigating Biological Systems Using Modeling Strategies and Software

About this book

Key features include: practical descriptions of how to analyse kinetic data; examples of how to develop and use models; and descriptions of several software packages.

Contents

Introduction: What is Modeling?; The Steps in Building a Model. The Difference Between Building a Model and Using a Model. Why Model Biological Systems?; Modeling Software: Review of Software. WinSAAM. Concepts and Tools of Modeling: Building Models in Sections. Techniques and Tools to Facilitate Model Development. Strategies for Modeling Biological Systems: Experimental Design and Data Collection. Starting Modeling and Developing a Model. Rejecting Hypotheses and Accepting a Model. Model Summarization. Multiple Studies Analysis. Information in the Model. Errors in Compartmental Modeling. Testing Robustness: Sensitivity, Identifiability, and Stability. Evaluating and Using Published Models: Why Use a Published Model?; Reviewing and Summarizing Published Models. The Model Translation Process. Verification and Validation. Using the Model. A Library of Models. Subject Index. Appendices.

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Biography

Meryl Wastney is an Associate Professor in the Department of Pediatrics and the Department of Biomathematics and Biostatistics at the Georgetown University Medical Center in Washington D.C. She received her Ph.D. in biochemistry from Lincoln College at the University of Canterbury in New Zealand. She was a Fogarty Fellow in the Laboratory of Mathematical Biology, NCI, NIH, Bethesda, Maryland for three years and joined the Department of Pediatrics at Georgetown University in 1983. She is the author of 30 articles and has presented over 40 invited lectures and workshops on modeling biological systems.