Molecular Genetics of Sex Determination

Out of Print

Edited By: SS Wachtel

518 pages

Publisher: Academic Press

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ISBN: 9780127289601 Hardback Dec 1993 Out of Print #31197

About this book Contents

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About this book

Reviews the basic biology of sex determination and summarises ground-breaking work in mouse, marsupial and Drosophila systems. Also covers current human genetics, clinical studies and the syndromes of abnormal sex differentiation.

Part I: S.S. Wachtel and T.R. Tiersch, The Search for the Male Determining Gene. A. Sinclair, The Cloning of SRY. J. Gubbay and R. Lovell-Badge, The Mouse Y Chromosome. A. McLaren, XX Sex Reversal in the Mouse. C.M. Nagamine, XY Sex Reversal in the Mouse. S. Ohno, Conservation of the X-Linkage Group in Toto by all Eutherian Mammals. M.F. Lyon, X-Chromosome Inactivation. G.K. Hampikian, D.W. Cooper, J.A. Marshall Graves, Sex Determination in Marsupials and Monotremes. C. Cronmiller and H.K. Salz, The Feminine Mystique: The Initiation of Sex Determination in Drosophila. Part II: U. Muller, The Human Y Chromosome. N.A. Affara and M.A. Ferguson-Smith, DNA Sequence Homology between the Human Sex Chromosomes. S.S. Wachtel, XX Sex Reversal in the Human. S.S. Wachtel and J.L. Simpson, XY Sex Reversal in the Human. K.Neeley and R.G. Rosenfeld, Phenotypic Correlations of X Chromosome Loss. L. Pinsky, M. Trifiro, L.K. Beitel, and M. Kaufman, Molecular Genetics of Androgen Insensitivity Syndromes in Man. M. Zachmann, Male Pseudohermaphroditism. M.I. New and C. Crawford, Molecular Genetics of Steroid 21-Hydroxylase Deficiency. N. Josso, S. Imbeaud, J.-Y. Picard, and R.L. Cate, The Gene for Anti-Mullerian Hormone. M.L. Gustafson and P.K. Donahoe, Mullerian Inhibiting Substance: Critical Roles in Sexual Differentiation.

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Out of Print

Edited By: SS Wachtel

518 pages

Publisher: Academic Press

Media reviews

Many of the individual contributions to this book are excellent stand-alone reviews, and the book as a whole constitutes a valuable source of information on sex determination, the X and Y chromosomes, and sexual development-bothnormal and abnormal-in humans and mice. I found the rather personal chapter by Hampikian et al. on marsupials to be particularly useful in conjunction with the Drosophila chapter; together they provide a sense of the commonalities and differences that determine sexual dimorphism in each of these groups relative to each other and to the eutherian mouse-human group. --SCIENCE "This book contains all you ever wanted to know about mammalian sex determination but were afraid to ask!... In all honesty, this is really a very good book which will provide an invaluable source of reference." --HEREDITY

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