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Academic & Professional Books  Organismal to Molecular Biology  Genetics

Mutation Detection: A Practical Approach

Handbook / Manual
Series: Practical Approach Series Volume: 188
Edited By: RGH Cotton, E Edkins and S Forrest
242 pages, Figs, tabs
Publisher: IRL Press
Mutation Detection: A Practical Approach
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  • Mutation Detection: A Practical Approach ISBN: 9780199636563 Paperback Feb 1998 Usually dispatched within 2-3 weeks
    £69.99
    #77081
  • Mutation Detection: A Practical Approach ISBN: 9780199636570 Hardback Dec 1998 Out of Print #84016
Selected version: £69.99
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About this book

Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations they contain. But mutation detection is time-consuming and expensive. This volume offers tried and tested protocols for a range of detection methods, from the labs of researchers in the field.

Contents

1. Single strand conformation polymorphism analysis; 2. Single-stranded conformation polymorphism and heteroduplex analysis; 3. Comprehensive mutation detection with denaturing gradient gel electrophoresis; 4. Cleavage using RNase to detect mutations; 5. Cleavage of mismatched bases using chemical reagents; 6. Mutation detection using T4 endonuclease VII; 7. Detection of mutations by hybridization with sequence-specific oligonucleotide probes; 8. DNA detection and sequence distinction through oligonucleotide ligation; 9. Detection of sequence variation using primer extension; 10. Selective amplification of specific alleles; 11. The protein truncation text (PTT); 12. Functional assay of the p53 tumour suppressor gene; 13. Advances in direct DNA sequencing for mutation scanning

Customer Reviews

Handbook / Manual
Series: Practical Approach Series Volume: 188
Edited By: RGH Cotton, E Edkins and S Forrest
242 pages, Figs, tabs
Publisher: IRL Press
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