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Natural Hosts of SIV: Implication in AIDS

By: Aftab A Ansari(Editor), Guido Silvestri(Editor)


Hardback | Aug 2014 | #221335 | ISBN-13: 9780124047341
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NHBS Price: £104.00 $137/€118 approx

About this book

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.


1. Overview
  Aftab Ansari and Guido Silvestri
2. Historical perspective
  Preston Marx
3. SIV infections in the wild
  Cristian Apetrei and Martine Peeters
4. Virology of SIVs
  Frank Kirchhoff
5. SIV Infection of Chimpanzees
  Jonathan Heeney, Edward James Donald Greenwood and Fabian Schmidt
6. Pathology of acute & chronic infection
  Francois Villinger and Sanjeev Gumber
7. Mucosal Immunity
  Jason Brenchley
8. Innate immunity
  Steven E. Bosinger and R. Keith Reeves
9.  Humoral immune responses
  Cynthia Ann Derdeyn and Reinhard Kurth
10. Cellular immune responses
  Amitinder Kaur
11. Chronic immune activation
  Donald Sodora
12. Pattern of infected cells
  Mirko Paiardini and Thomas Howerton Vanderford V
13. Viral transmission
  Ivona Pandrea and Ann Chahroudi
14. Genetics of the host
  Lutz Walter
15.  The different modes of HIV/SIV control in monkeys and humans
  Lisa Chakrabarti
16. Humans resembling natural hosts
  Amalio Telenti and Paul McLaren
17. Implications for HIV infection
  Aftab Ansari and Guido Silvestri

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