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This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.
Preface
Foreword
Acknowledgments
Contributors
PART I OXIDATIVE STRESS IN VERTEBRATES
1 Generation of Reactive Oxygen Species in the Brain: Signaling for Neural Cell Survival or Suicide 3
2 Free Radicals, Signal Transduction, and Human Disease 17
3 Oxidative Stress and its Biochemical Consequences in Mitochondrial DNA Mutation-Associated Diseases: Implications of Redox Therapy for Mitochondrial Diseases 33
4 Oxidative Stress in Kainic Acid Neurotoxicity: Implications for the Pathogenesis of Neurotraumatic and Neurodegenerative Diseases 51
5 Survival Strategy and Disease Pathogenesis According to the Nrf2-Small Maf Heterodimer 63
6 Caloric Restriction and Oxidative Stress 83
7 Pathogenesis of Neurodegenerative Diseases: Contribution of Oxidative Stress and Neuroinflammation 103
8 Neurosteroids in Oxidative Stress-Mediated Injury in Alzheimer Disease 117
9 Oxidative Stress in Adult Neurogenesis and in the Pathogenesis of Alzheimer Disease 129
10 Oxidative Stress and Parkinson Disease 139
11 Oxidative Stress in Cardiovascular Diseases 153
12 Oxidative Stress and Aging: A Comparison between Vertebrates and Invertebrates 167
13 Oxidative Stress-Mediated Signaling Pathways by Environmental Stressors 175
14 Selenoproteins in Cellular Redox Regulation and Signaling 195
15 Antioxidant Therapy and its Effectiveness in Oxidative Stress-Mediated Disorders 209
16 The Protective Role of Grape Seed Polyphenols Against Oxidative Stress in Treating Neurodegenerative Diseases 235
17 Pharmacological and Therapeutic Properties of Propolis (Bee Glue) 245
PART II OXIDATIVE STRESS IN INVERTEBRATES
18 Endocrine Control of Oxidative Stress in Insects 261
19 Oxidative Stress in the Airway System of the Fruit Fly Drosophila melanogaster 271
20 Molecular Mechanisms of Antioxidant Protective Processes in Honeybee Apis mellifera 279
21 Molecular Basis of Iron-induced Oxidative Stress in the Honeybee Brain: A Potential Model System of Olfactory Dysfunction in Neurological Diseases 295
22 Modulation of Oxidative Stress by Keap1/Nrf2 Signaling in Drosophila: Implications for Human Diseases 309
23 Orchestration of Oxidative Stress Responses in Drosophila melanogaster: A Promoter Analysis Study of Circadian Regulatory Motifs 327
24 The Protective Role of Sestrins Against Chronic TOR Activation and Oxidative Stress 337
25 Current Advances in the Studies of Oxidative Stress and Age-Related Memory Impairment in C. elegans 347
26 Oxidative Challenge and Redox Sensing in Mollusks: Effects of Natural and Anthropic Stressors 361
27 Perspective and Directions for Future Studies 377
Index
Tahira Farooqui has published extensively on drug receptor interactions, biogenic amines in vertebrate and invertebrate nervous systems, glycerophospholipid and sphingolipid metabolism, and molecular mechanisms in the brain, as well as on the neuromodulatory role of octopamine in the reinforcement pathway involved in olfactory learning and memory.
Akhlaq A. Farooqui is a leader in the fields of signal transduction, brain phospholipase A2, bioactive ether lipid metabolism, and polyunsaturated fatty acid metabolism, among others. Farooqui has published on the generation and identification of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid-mediated neurotoxicity by lipidomics.
