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Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focussing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases.
Transcription and Splicing Transcription Termination Histone RNA Processing SnRNP Biogenesis/Protein Arginine Methylation Pre-mRNA Splicing & Catalytic Mechanisms Alternative Splicing Regulation in the Nervous System, Impact & Mechanism Visualization and Manipulation of Alternative Splicing in Vivo Splicing Regulation and Diseases Translation Control Nonsense-mediated mRNA Decay RNA Interference Evolution of Non-protein Coding RNA Genes Additional Chapters will added on the topics of: 1. non-coding ncRNA: 2.miRNA; 3. RNA modifications [directed by C/D and H/ACA box snoRNAs ] 4. RNA editing
Dr. Jane Y. Wu is the Charles Louis Mix Professor in Neurology at Lurie Cancer Center and the Center for Genetic Medicine of Northwestern University in Chicago, USA. Having obtained her degree from Stanford Univeristy and postdoctoral training at Harvard University, Dr. Wu has been studying molecular mechanisms underlying pre-mRNA splicing and neurodevelopment/degeneration, both linking basic biology to human diseases.