mRNA Metabolism and Post-Transcriptional Gene Regulation

About this book

Post-transcriptional reactions have been implicated in a number of clinical conditions (e.g. lupus, and rheumatoid arthritis), and regulatory mechanisms are the target of potential therapeutic strategies. This book provides a comprehensive overview of the various modes of gene regulation that exist post-transcriptionally. It uses selected well-characterized examples to illustrate the generally applicable principles for regulation that exist throughout the life of an RNA molecule.

Contents

Partial table of contents: RNA Structure (E. Puglisi & J. Puglisi). Transcription and Transcriptional Control: An Overview (I. Olave, et al.). Constitutive and Alternative mRNA Splicing (S. Bernstein & D. Hodges). mRNA Polyadenylation: Functional Implications (E. Baker). RNA Export from the Nucleus (L. Maquat). The Intracellular mRNA Sorting System: Postal Codes, Zip Codes, Mail Bags and Mail Boxes (O. Steward & R. Singer). The Fundamentals of Translation Initiation (H. Huang & T. Donahue). Mechanisms of mRNA Turnover in Eukaryotic Cells (S. Tharun & R. Parker). Control of mRNA Decay in Plants (A. van Hoof & P. Green). mRNA Metabolism and Cancer (M. Korth & M. Katze). Translational Regulation in Animal Virus--Infected Cells (R. Schneider). RNA Decay by the Interferon--Regulated 2--5A System as a Host Defense Against Viruses (R. Silverman & N. Cirino). Control of mRNA Stability During Herpes Simplex Virus Infection (G. Read). Regulation of mRNA Expression in HIV--1 and Other Retroviruses (B. Felber). Index.

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