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Signal Transduction

By: Lewis Cantley(Editor), Tony Hunter(Editor), Richard Sever(Editor), Jeremy Thorner(Editor), Fischer Edmond(Foreword By)

Cold Spring Harbor Laboratory Press

Hardback | Feb 2014 | #211551 | ISBN-13: 9780879699017
Availability: Usually dispatched within 6 days Details
NHBS Price: £104.00 $133/€116 approx

About this book

Signal transduction pathways are molecular circuits that define how cells communicate with each other and respond to their environment. This new textbook for the first time provides a comprehensive view of the subject by covering both the basic mechanisms involved and the roles of signal transduction in fundamental biological processes. It starts by describing the basic players – signals, receptors, second messengers, and effectors – before comprehensively mapping the various different signaling pathways that operate in cells. It then goes on to provide detailed descriptions of how signal transduction functions in essential processes such as cell growth and division, metabolism, sensory perception, immunity, and reproduction.


    Edmond Fischer
1. Signals and Receptors
    Carl Henrik-Heldin, Benson Lu, Ron Evans, and Silvio Gutkind
2. General Principles and Mechanisms of Protein Regulation in Signal Transduction
    Michael J. Lee and Michael B. Yaffe
3. Second messengers
    Alexandra Newton and Susan Taylor
4. Signaling Networks: Computational Capabilities and Decision-making
    Evren U. Azeloglu and Ravi Iyengar
MAP Kinase Pathways
    Deborah Morrison
PI3K-PKB/Akt Pathway Signaling
    Brian A. Hemmings and David F. Restuccia
mTOR Signaling
    Mathieu Laplante and David M. Sabatini
Calcium Signaling
    Martin D. Bootman
The Cyclic AMP Pathway
    Paolo Sassone-Corsi
The Wnt Signaling
    Roel Nusse
Hedgehog Signaling
    Philip W. Ingham
Notch Pathway
    Raphael Kopan
Signaling by the TGF-? Superfamily
    Jeffrey L. Wrana
JAK/STAT Pathway
    Douglas Harrison
Toll-like Receptor Signaling
    Kian-Huat Lim and Louis M. Staudt
Immunoreceptor Signaling
    Lawrence E. Samelson
Signaling by Nuclear Receptors
    Richard Sever and Christopher K. Glass
The Hippo Pathway
    Kieran F. Harvey and Iswar K. Hariharan
5. Signaling to the G1 Cell Cycle
    Robert J. Duronio and Yue Xiong
6. Signaling Pathways that Regulate Cell Division
    Nicholas Rhind and Paul Russell
7. Cell Growth and Metabolism
    Patrick S. Ward and Craig B. Thompson
8. Signal Transduction and the Regulation of Cell Migration
    Peter Devreotes and Rick Horwitz
9. Signaling Pathways in Cell Polarity
    Luke M. McCaffrey and Ian G. Macara
10. Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning
    Norbert Perrimon, Chrysoula Pitsouli, and Ben-Zion Shilo
11. Signaling by Sensory Receptors
    David Julius and Jeremy Nathans
12. Synaptic Signaling in Learning and Memory
    Mary B. Kennedy
13. Signaling in Muscle Contraction
    Ivana Y. Kuo and Barbara E. Ehrlich
14. Organismal Carbohydrate and Lipid Homeostasis
    D. Graham Hardie
15. Signaling in Innate Immunity and Inflammation
    Kim Newton and Vishva Dixit
16. Signaling in Lymphocyte Activation
    Doreen Cantrell
17. Vertebrate Reproduction
    Sally Kornbluth and Rafael Fissore
18. Stress Responses
    Gökhan Hotamisligil and Roger J. Davis
19. Death Signaling
    Douglas R. Green and Fabien Llambi
20. Subversion of Cell Signaling by Pathogens
    Kim Orth and Neal Alto
21. Signaling in Cancer
    Richard Sever and Joan S. Brugge
22. Outlook
    Jeremy Thorner, Lewis Cantley, Tony Hunter, and Richard Sever

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