Susceptibility to Infectious Diseases The Importance of Host Genetics

About this book

In the last ten years, substantial progress has been made in identifying why some people are particularly susceptible to specific infectious diseases. Extensive evidence has now accumulated that host genes are important determinants of the outcome of infection for many common pathogens. Susceptibility to Infectious Diseases summarises the advances that have been made in understanding the complexity of host genetic susceptibility. The diseases covered include those of great public health importance such as malaria and HIV, and those of current topical interest such as Creutzfeldt-Jakob disease. Many different techniques have been used to identify host genes involved in infectious disease susceptibility. Each chapter describes how these discoveries were made and Susceptibility to Infectious Diseases is therefore useful to anyone planning genetic studies on a multi-factorial disease, regardless of whether it has an infectious etiology.

Contents

1. Introduction Richard Bellamy
2. Application of genetic epidemiology to dissecting host susceptibility/resistance to infection illustrated with the study of common mycobacterial infections Alexandre Alcais and Laurent Abel
3. The diverse genetic basis of immunodeficiencies Mauno Vihinen
4. Genetic diversity in the major histocompatibility complex and the immune response to infectious diseases Leland J. Yee and Mark R. Thursz
5. The cystic fibrosis transmembrane conductance regulator Alan W. Cuthbert
6. The influence of inherited traits on malaria infection David J. Roberts, Tyler Harris and Thomas Williams
7. Polymorphic chemokine receptor and ligand genes in HIV infection Jianming (James) Tang and Richard A. Kaslow
8. N-ramp and resistance in intracellular pathogens Philippe Gros and Erwin Schurr
9. The interleukin-12-interferon-γ loop is required for protective immunity to experimental and natural infections by Mycobacterium Marion Bonnet, Claire Soudais and Jean-Laurent Casanova
10. Mannose-binding lectin deficiency and susceptibility to infectious disease Dominic L. Jack, Nigel J. Klein and Malcolm W. Turner
11. Blood group phenotypes and infectious diseases C. Caroline Blackwell, Donald M. Weir, Abdulhamid M. Alkout, Omar R. El Ahmer, Doris A. C. Mackenzie, Valerie S. James, J. Matthias Braun, Osama M. Almadani and Anthony Busuttil
12. Genetics of human susceptibility to infection and hepatic disease caused by schistosomes Alain J. Dessein, Nasureldin El Wali, Sandrine Marquet, Laurent Abel, Virmondes Rodrigues Jr., Carole Eboumbou Moukoko, Helia Dessein, Laurent Argiro, Sandrine Henri, Dominique Hillaire, Gachuhi Kimani, Aluizio Prata, Mubarak Magzoub and Christophe Chevillard
13. Genetic susceptibility to prion diseases Matthew Bishop and J. W. Ironside

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Biography

Contributors:
- Richard Bellamy
- Alexandre Alcais
- Laurent Abel
- Mauno Vihinen
- Leland J. Yee
- Mark R. Thursz
- Alan W. Cuthbert
- David J. Roberts
- Tyler Harris
- Thomas Williams
- Jianming (James) Tang
- Richard A. Kaslow
- Philippe Gros
- Erwin Schurr
- Marion Bonnet
- Claire Soudais
- Jean-Laurent Casanova
- Dominic L. Jack
- Nigel J. Klein
- Malcolm W. Turner
- C. Caroline Blackwell
- Donald M. Weir
- Abdulhamid M. Alkout
- Omar R. El Ahmer
- Doris A. C. Mackenzie
- Valerie S. James
- J. Matthias Braun
- Osama M. Almadani
- Anthony Busuttil
- Alain J. Dessein
- Nasureldin El Wali
- Sandrine Marquet
- Laurent Abel
- Virmondes Rodrigues Jr
- Carole Eboumbou Moukoko
- Helia Dessein
- Laurent Argiro
- Sandrine Henri
- Dominique Hillaire
- Gachuhi Kimani
- Aluizio Prata
- Mubarak Magzoub
- Christophe Chevillard
- Matthew Bishop
- J. W. Ironside