About this book
This must-have cell signaling title will appeal to researchers across molecular biology, biochemistry, cell biology and genetics. The articles are written and edited by experts in the field and emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, the regulation of endoplasmic reticulum function, control of cell cycle progression and apoptosis and the modulation of the activities of mitochondria and other organelles.
Contents
244 Nuclear Receptor Coactivators
245 Corepressors in Mediating Repression by Nuclear Receptors
246 Steroid Hormone Receptor Signaling
247 Role of COUP-TFII in Congenital Diaphragmatic Hernia
248 Nuclear Receptors in Drosophila melanogaster
249 JAK-STAT Signaling
250 FOXO Transcription Factors: Key Targets of the PI3K-Akt Pathway
251 The Multi-gene Family of Transcription Factor AP-1
252 NF-KB: a Key Integrator of Cell Signaling
253 Transcriptional Regulation via the cAMP Responsive Activator CREB
254 The NFAT Family: Structure, Regulation and Biological Functions
255 Ubiquitination/Proteasome
256 The SMADs
257 Complexity of Stress Signaling
258 Signal Transduction in the Escherichia coli SOS Response
259 Oxidative Stress and Free Radical Signal Transduction
260 Screening Approaches to Identify Genes Required for DNA Double-Strand Break
261 Radiation Responses in Drosophila
262 Double-strand Break Recognition and its Repair by Non-homologous End Joining
263 ATM-Mediated Signaling Defends the Integrity of the Genome
264 Signaling to the p53 Tumor Suppressor through Pathways
265 The p53 Master Regulator and Rules of Engagement with Target Sequences
266 Nuclear and Cytoplasmic Functions of Abl Tyrosine Kinase
267 Radiation-induced Cytoplasmic Signaling
268 The Heat-Shock Response and the Stress of Misfolded Proteins
269 Hypoxia-Mediated Signaling Pathways
270 Regulation of mRNA Turnover by Cellular Stress
271 Oncogenic Stress Responses
272 Ubiquitin and FANC Stress Responses
273 Stress and g -H2AX
274 Translational Control by Amino Acids and Energy
275 Translation Control and Insulin Signaling
276 ER and oxidative stress: Implications in disease
277 Regulation of mRNA Turnover
278 Signaling to Cytoplasmic Polyadenylation and Translation
279 Translational Control in Invertebrate Development
280 The Role of Alternative Splicing During the Cell Cycle and Programmed Cell Death
281 Signaling Pathways that Mediate Translational Control of Ribosome Recruitment
282 The SWI/SNF and RSC Nucleosome Remodeling Complexes
283 ISWI Chromatin Remodeling Complexes
284 The INO80 Chromatin Remodeling Complex
285 Histone Acetylation Complexes
286 Regulation of Histone Deacetylase Activities and Functions by Phosphorylation and
287 Histone Methylation: Chemically Inert But Chromatin Dynamic
288 Histone Phosphorylation: Chromatin Modifications
289 Histone Variants: Signaling or Structural Modules?
290 Silent Chromatin Formation and Regulation in the Yeast Saccharomyces cerevisiae
291 Gene Silencing and Chromatin Modification by Polycomb Complexes
292 Histone Ubiquitination
293 Chromatin-mediated Control of Gene Expression in Innate Immunity and Inflammation
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Biography
Ralph A. Bradshaw is Professor of Chemistry and Pharmaceutical Chemistry; and Deputy Director, Mass Spectrometry Facility, University of California, San Francisco, as well as Professor Emeritus, Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, Irvine, CA. He is also Editor of the journal "Molecular Cellular Proteomics"
Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the "Journal of Lipid Research".
