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Aging of the Genome: The Dual Role of DNA in Life and Death

By: Jan Vijg

372 pages, Figs, tabs

Oxford University Press

Paperback | Feb 2007 | #163434 | ISBN-13: 9780198569237
Availability: Usually dispatched within 5 days Details
NHBS Price: £60.99 $80/€69 approx
Hardback | Jan 2007 | #163435 | ISBN-13: 9780198569220
Availability: Usually dispatched within 2-3 weeks Details
NHBS Price: £120.00 $157/€136 approx

About this book

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

'This is a work of real scholarship...'Nature, Vol 447, 17 May 2007


Preface; 1. Introduction; 2. The Logic of Aging; 3. Genome Structure and Function; 4. Genome Maintenance; 5. Genome Instability and Accelerated Aging; 6. The Aging Genome; 7. From Genome to Phenome; 8. A Genomic Limit to Life?; References and Glossary; Literature References

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