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Academic & Professional Books  Organismal to Molecular Biology  Genetics & Genomics

Aging of the Genome The Dual Role of DNA in Life and Death

By: Jan Vijg
372 pages, Figs, tabs
Aging of the Genome
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  • Aging of the Genome ISBN: 9780198569237 Paperback Jan 2007 Not in stock: Usually dispatched within 6 days
  • Aging of the Genome ISBN: 9780198569220 Hardback Jan 2007 Out of Print #163435
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About this book

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.


Preface; 1. Introduction; 2. The Logic of Aging; 3. Genome Structure and Function; 4. Genome Maintenance; 5. Genome Instability and Accelerated Aging; 6. The Aging Genome; 7. From Genome to Phenome; 8. A Genomic Limit to Life?; References and Glossary; Literature References

Customer Reviews

By: Jan Vijg
372 pages, Figs, tabs
Media reviews

'This is a work of real scholarship...'Nature, Vol 447, 17 May 2007

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