Books  Animal & General Biology  Genetics 

Anatomy of Gene Regulation: A Three-Dimensional Structural Analysis

By: Panagiotis A Tsonis

294 pages, 253 Col plates, 76 illus, figs

Cambridge University Press

Paperback | Jan 2003 | #128052 | ISBN: 0521804744
Availability: Usually dispatched within 6 days Details
NHBS Price: £66.99 $89/€77 approx
Hardback | Jan 2003 | #128051 | ISBN: 0521800307
Availability: Usually dispatched within 6 days Details
NHBS Price: £129.00 $171/€148 approx

About this book

Presents the parts and processes of gene regulation at the three-dimensional level and in full-colour. Beginning with a general introduction to three-dimensional structures, the book looks at the organization of the genome, the structure of DNA, DNA replication and transcription, splicing, protein synthesis, and ultimate protein death.

' ! beautiful and informative three-dimensional images of the nucleosome, RNA and DNA polymerases and the ribosome. Years of genetic and biochemical data spring to life when mapped onto these structures, and future experiments can be designed with much greater precision. Many of us who teach molecular biology at the undergraduate or graduate level have tried to convey this excitement by incorporating structures into our teaching. What might otherwise be dry descriptions of protein interactions or catalytic steps take on greater clarity and tangibility when students can see the molecules. Pangiotis Tsonis has compiled and summarized a great deal of structural information in his new book entitled Anatomy of Gene Regulations. It's a terrific idea and a laudable effort.' Nature Structural Biology 'So this book presents a very wide-ranging coverage of three-dimensional structural aspects only in a concise and attractive format with very readable text ! I enjoyed this book as a handy source to dip into for structural insights and for the author's obvious pleasure in communicating these to his audience.' Heredity


Preface; 1. A general introduction to 3-D structures; 2. The higher organization of the genome; 3. Structure of DNA and telomeres; 4. DNA replication; 5. Transcription in prokaryotes; 6. Transcription in eukaryotes; 7. Splicing; 8. Modifications of mRNA; 9. Compartmentalization of transcription; 10. Protein synthesis; 11. The birth and death of proteins; Index.

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