This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.
I. Introduction Chapters
1. Overview of Biotechnology Tools for Green Synthesis: Enzymes, Cells and their Tunability by Engineering
2. How Green can the Industry Become with Biotechnology
3. Emerging Enzymes and Their Synthetic Applications
4. Reaction Efficiencies and Green Chemistry Metrics of Biotransformations
II. Application and Case Studies - Pharmaceuticals and Fine Chemicals
5. Biocatalytic Routes to Chiral Intermediates for Development of Drugs
6. Transflutaminase for Protein Drug Modification: PEGylation and Beyond
7. Microbial Production of Plant-Derived Pharmaceutical Natural Products through Metabolic Engineering: Artemisinin and Beyond
8. Toward Greener Therapeutic Proteins
III. Application and Case Studies - Flavor & Fragrance, Agrochemicals and Fine Chemicals
9. Opportunities for Biocatalysis in the Flavor, Fragrance and Cosmetic Industry
10. Application of Biocatalysis in the Agrochemical Industry
11. Green Production of Fine Chemicals by Isolated Enzymes
12. Whole Cell Production of Fine Chemicals and Intermediates
IV. Applications and Case Studies - Polymers and Renewable Chemicals
13. Green Chemistry for the Production of Biodegradable, Biorenewable, Biocompatible Polymers
14. Enzymatic Degradation of Lignocellulosic Biomass
15. Bioconversion of Renewable-Plant Oils
16. Microbial Bioprocesses for Industrial Scale Chemical Production
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JUNHUA (Alex) TAO is currently CEO of Metabomics, Inc. Prior to that; he was the CSO of Elevance Renewable Sciences, and the creator and head of the Biotransformations Group at Pfizer, where he was also a core member of the API Development Team. He co-authored over 60 publications including "Biocatalysis for the Pharmaceutical Industry" (Wiley, 2009) and co-invented over 20 patents. In addition, he was the recipient of the Pfizer Achievement Award, the Pfizer Green Chemistry Award, and a key member of the Lyrica process development team, which won the IChemE Award for Excellence in Green Chemistry and Engineering (2006).
ROMAS JOSEPH KAZLAUSKAS is Professor of Biochemistry, Molecular Biology and Biophysics at the BioTechnology Institute of the University of Minnesota, Twin Cities. He is the coauthor of over eighty papers and reviews, and the book "Hydrolases in Organic Synthesis". He also served as the co-chair of two Gordon Research Conferences, one on biocatalysis and one on green chemistry.