Cell Adhesion Molecules Cellular Recognition Mechanisms

About this book

The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems.

The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression.

This is a reprint of the original 1993 edition.

Contents

- Integrin Expression and Epithelial Cell Differentiation; V. Quaranta
- Fibronectin Mutations in Mice; E.N. Georges et al.
- Extracellular and Intracellular Functions of VLA Proteins; M.E. Hemler et al.
- Signal Transduction from Leukocyte Integrins; E.J. Brown
- Coordinate Role for Proteoglycans and Integrins in Cell Adhesion; J.B. McCarthy et al.
- Adhesion Molecules at Endothelial Cell to Cell Junctions; M.G. Lampugnani et al.
- Activation of LFA1; C.G. Figdor, Y. van Kooyk
- Interaction of Cytotoxic T Lymphocytes with Autologous Melanoma; A. Anichini et al.
- Tumor Cell-Endothelial Cell Interactions during Blood Borne Metastasis; G.L. Nicolson et al.
- Adhesion Mechanisms in Lymphoma and Carcinoma Metastasis; G. La Riviere et al.
- CD44 and Splice Variants of CD44 in Normal Differentiation and Tumor Progression; P. Herrlich et al.

6 additional articles

Index

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