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This first book to adopt a problem-based approach teaches the true basics of the subject through illustrated everyday case studies. The editor's extensive experience in writing textbooks and his close relationship to the authors ensure that the contributions are presented in a pedagogically uniform and highly motivating fashion. Each chapter introduces a different biological problem taken from everyday lab work, such that students learn how to think in order to solve problems in biology by using techniques and tools taken from chemistry. A must-have for students in chemistry, biology and biochemistry.
Foreword Introduction Ras Proteins, Synthesis, Ras Cycle Rab Proteins, Structure, Biochemistry Proteases, Proteasome Activity-Based Proteomics FK506 Regulation of Gene Expression, Transcription Protein Synthesis, Native Chemcial Ligation Expressed Protein Ligation Microarray Technologies APT1, Ras Palmitoylation Carbohydrates Yeast Based Chemical Genomics Target Identification BIOS, PSSC, Natural Products Alzheimer Diversity Oriented Synthesis Kinases, Orthogonal Chemical Genetics Glossary
Herbert Waldmann received his PhD in 1985 at the University of Mainz under Prof. Kunz in organic chemistry after which he completed a postdoctoral appointment with Prof. G. Whitesides at Harvard University. He was appointed as Professor of Organic Chemistry at the University of Bonn (1991), full Professor of Organic Chemistry at the University of Karlsruhe (1993), and Director at the MPI of Molecular Physiology Dortmund and Professor of Organic Chemistry at the University of Dortmund (1999). His research interests lie in compound libraries, solid-phase synthesis, and Ras proteins. Petra Janning studied chemistry at the University of Munster (Germany) and did her thesis at the Institute for Analytical Sciences in Dortmund (PhD 1995). After different positions where she worked in the area of analytical chemistry and on the borderline between chemistry and biology she joined the Max Planck Institute of Molecular Physiology, Dortmund in the department of Prof. Dr. H. Waldmann, where she is currently working. She is responsible for the Bioorganic Practical Course and the analytics in the department. She focused her work on the development of chromatographic and mass spectrometric methods used in the institute.
A"The approach taken by the editors is straightforward and easy to comprehend, since the methods and techniques are introduced by examples from actual research projects.A" (Angewandte Chemie, October 2009)