DNA Repair and Mutagenesis

About this book

Major revision of the comprehensive text (first published in 1985 as DNA Repair) which deals with the manifold ways in which living cells respond to genomic injury and alterations, including both spontaneous and environmentally induced DNA damage. In addition to the extensively revised material on DNA repair, there are four new chapters by Graham Walker on mutagenesis.

Contents

DNA damage; Mutations; The reversal of base damage; Base excision repair; Nucleotide excision repair in prokaryotes; Nucleotide excision repair in lower eukaryotes; Nucleotide excision repair in mammalian cells: general considerations and chromatin dynamics; Nucleotide excision repair in mammalian cells: genes and proteins; Mismatch repair; The SOS response and recombinational repair in prokaryotes; Mutagenesis in prokaryotes; Mutagenesis in eukaryotes; Other DNA damage tolerance responses in eukaryotes; Hereditary diseases with defective responses to DNA damage

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