Genome Duplication

About this book

Using model organisms from the three domains of life (Bacteria, Archaea, and Eukarya), "Genome Duplication" explains the principle molecular mechanisms of DNA replication and shows how the process is linked to cell division. This approaches allows the book to give insight into how genome duplication evolved, and how its regulation is relevant to the understanding and treatment of human disease, especially cancer. By providing a comprehensive and readable overview, "Genome Duplication" provides an excellent starting point for undergraduate and graduate students.

Contents

1. Genomes 2. Life 3. Replication Forks 4. Replication Proteins: leading strand synthesis 5. Replication Proteins: lagging strand synthesis 6. Termination 7. Chromatin Assembly Cohesion and Modification 8. Replicons 9. Replication Origins 10. Origin Paradigms 11. Initiation 12. Cell Cycles 13. Checkpoints 14. Medical Relevance 15. Evolution of Cellular Replication Machineries

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Biography

National Institute of Child Health and Human Development, USA Hutchison MRC Research Centre, UK