Mammalian Development Networks, Switches, and Morphogenetic Processes

About this book

During the last decade, research in developmental biology has undergone a dramatic change brought about by the availability of whole genome sequences from diverse organisms, the availability of transcriptomes and epigenomes, advanced imaging techniques and the increased understanding of the role of stem cells in organ and tissue development and regeneration. These advances have been integrated with traditional approaches of genetic manipulations and detailed phenotypic analyses in experimental model organisms such as the mouse.

Mammalian Development: Networks, Switches, and Morphogenetic Processes provides a contemporary overview of the conceptual framework of molecular and cellular mechanisms of mammalian development, and a glimpse into future directions in mammalian developmental biology and its relevance to cellular and tissue therapy. Major areas of focus are transcriptional and epigenetic switches and the activity of genetic networks in cell differentiation, the role of signaling pathways, and tissue modeling and organ formation. Another major focus is on the translation of basic knowledge of developmental processes into stem cell biology, directed differentiation of pluripotent or lineage-biased progenitors, and the potential for regenerative medicine.

Mammalian Development: Networks, Switches, and Morphogenetic Processes is aimed at senior undergraduates interested in the scope of modern developmental biology, graduate students and post-doctoral fellows who are beginning to explore the mouse as a model system for studying vertebrate development and its relevance to human diseases, and established scientists in fields outside the traditional areas of developmental biology who are looking to apply their knowledge and expertise in new ways.

Contents

Preface
 
SECTION I. GENOME, EPIGENOME, PROTEOME, AND CELL SIGNALING
Summary
    Janet Rossant
 
1 Pluripotency in the Embryo and in Culture
    Jennifer Nichols and Austin Smith
2 Genomic Imprinting and Epigenetic Control of Development
    Andrew Fedoriw, Joshua Mugford, and Terry Magnuson
3 microRNAs as Developmental Regulators
    Kathryn N. Ivey and Deepak Srivastava
4 Proteomic Analysis of Stem Cell Differentiation and Early Development
    Dennis Van Hoof, Jeroen Krijgsveld, and Christine Mummery
5 Signaling in Cell Differentiation and Morphogenesis
    M. Albert Basson
 
SECTION II. MORPHOGENETIC PROCESSES
Summary
    W. James Nelson
 
6 Branching Morphogenesis: From Cells to Organs and Back
    Amanda Ochoa-Espinosa and Markus Affolter
7 Polarity in Mammalian Epithelial Morphogenesis
    Julie Roignot, Xiao Peng, and Keith Mostov
8 Cell Division Modes and Cleavage Planes of Neural Progenitors during Mammalian Cortical Development
    Fumio Matsuzaki and Atsunori Shitamukai
9 Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases
    Paola Nisticò, Mina J. Bissell, and Derek C. Radisky
10 Molecular Mechanisms of Cell Segregation and Boundary Formation in Development and Tumorigenesis
    Eduard Batlle and David G. Wilkinson
11 The Synchrony and Cyclicity of Developmental Events
    Yumiko Saga
12 Intercellular Interactions, Position, and Polarity in Establishing Blastocyst Cell Lineages and Embryonic Axes
    Robert O. Stephenson, Janet Rossant, and Patrick P.L. Tam
13 The Dynamics of Morphogenesis in the Early Mouse Embryo
    Jaime A. Rivera-Pérez and Anna-Katerina Hadjantonakis
 
SECTION III. SIGNALS AND SWITCHES IN LINEAGE SPECIFICATION, TISSUE DIFFERENTIATION, AND ORGANOGENESIS
Summary
    Patrick P.L. Tam
 
14 Hematopoiesis
    Michael A. Rieger and Timm Schroeder
15 Primordial Germ Cells in Mice
    Mitinori Saitou and Masashi Yamaji
16 Signals and Switches in Mammalian Neural Crest Cell Differentiation
    Shachi Bhatt, Raul Diaz, and Paul A. Trainor
17 Molecular Control of Neurogenesis: A View from the Mammalian Cerebral Cortex
    Ben Martynoga, Daniela Drechsel, and François Guillemot
18 Development and Homeostasis of the Skin Epidermis
    Panagiota A. Sotiropoulou and Cedric Blanpain
19 Adipogenesis
    Kelesha Sarjeant and Jacqueline M. Stephens
20 Blood and Lymphatic Vessel Formation
    Victoria L. Bautch and Kathleen M. Caron
21 Building Muscle: Molecular Regulation of Myogenesis
    C. Florian Bentzinger, Yu Xin Wang, and Michael A. Rudnicki
22 Development of the Endochondral Skeleton
    Fanxin Long and David M. Ornitz
23 Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages
    Maria Jussila and Irma Thesleff
24 Eye Development and Retinogenesis
    Whitney Heavner and Larysa Pevny
25 Molecular Mechanisms of Inner Ear Development
    Doris K. Wu and Matthew M. Kelley
26 Signaling and Transcriptional Networks in Heart Development and Regeneration
    Benoit G. Bruneau
27 Signaling Networks Regulating Development of the Lower Respiratory Tract
    David M. Ornitz and Yongjun Yin
28 Deconstructing Pancreas Developmental Biology
    Cecil M. Benitez, William R. Goodyer, and Seung K. Kim
29 Transcriptional Networks in Liver and Intestinal Development
    Karyn L. Sheaffer and Klaus H. Kaestner
30 Mammalian Kidney Development: Principles, Progress, and Projections
    Melissa H. Little and Andrew P. McMahon
 
Index

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