736 pages, colour illustrations
Dendrites are complex neuronal structures that receive and integrate synaptic input from other nerve cells. They therefore play a critical role in brain function. Although dendrites were discovered over a century ago, due to the development of powerful new techniques there has been a dramatic resurgence of interest in the properties and function of these beautiful structures.
This is the third edition of the first book devoted exclusively to dendrites. It contains a comprehensive survey of the current state of dendritic research across a wide range of topics, from dendritic morphology, evolution, development, and plasticity through to the electrical, biochemical and computational properties of dendrites, and finally to the key role of dendrites in brain disease. The third edition has been thoroughly revised, with the addition of a number of new chapters and comprehensive updates or rewrites of existing chapters by leading experts.
Dendrites will be of interest to researchers and students in neuroscience and related fields, as well as to anyone interested in how the brain works.
New to this edition:
- The third edition contains a comprehensive revision of all chapters from the second edition, which in many cases have been completely rewritten by leading experts.
- Four new chapters.
- 40% new material, with the other 60% thoroughly revised
Review from a the previous edition:
"For those who need persuading that dendrites are at the core of brain science, this new edition provides definitive evidence. Of special interest are the new methodologies, many introduced by the editors and their co-authors, that show in increasingly exquisite detail how the branching structures of dendrites and spines provide a rich substrate for biochemical, functional, and computational compartments. A major theme is how these compartments play essential roles in sensory processing, learning and memory. Brain scientists take note: dendrites drive the circuits that drive behavior."
– Gordon M. Shepherd, Professor of Neuroscience, Yale University School of Medicine, USA
1: Kristen M. Harris and Josef Spacek: Dendrite structure
2: Samuel S.-H. Wang, Anthony E. Ambrosini, and Gayle M. Wittenberg: Evolution and Scaling of Dendrites
3: Hollis T. Cline: Dendrite Development
4: Franck Polleux, Anirvan Ghosh, and Wesley B. Grueber: Molecular Determinants of Dendrite and Spine Development
5: Irena Vlatkovic and Erin M. Schuman: Local translation in dendrites
6: Natasha K. Hussain and Richard L. Huganir: Structure and Molecular Organization of the Postsynaptic Density
7: Zoltan Nusser: Subcellular Distribution of Ligand- and Voltage-Gated Ion Channels
8: R. Angus Silver, Andrew F. MacAskill, and Mark Farrant: Neurotransmitter-gated ion channels in dendrites
9: Jeffrey C. Magee: Dendritic Voltage-gated Ion Channels
10: Fritjof Helmchen and U. Valentin Nägerl: Biochemical compartmentalization in dendrites
11: Adam Carter and Bernardo Sabatini: Spine Calcium Signaling
12: Nelson Spruston, Greg Stuart, and Michael Häusser: Principles of Dendritic Integration
13: Lucy Palmer, Masanori Murayama, and Matthew Larkum: Dendritic integration in vivo
14: Wilfrid Rall: Modeling dendrites: A personal perspective
15: Etay Hay, Albert Gidon, Michael London, and Idan Segev: A theoretical view of the neuron as an input-output computing device
16: Bartlett W. Mel: Towards a simplified model of an active dendritic tree
17: Hermann Cuntz: Modelling dendrite shape
18: Jérôme Maheux, Robert C. Froemke, and P. Jesper Sjöström: Functional Plasticity at Dendritic Synapses
19: Tobias Bonhoeffer and Pico Caroni: Structural plasticity in dendrites and spines
20: Ryohei Yasuda: Molecular signaling during plasticity of dendritic spines
21: Nathaniel Urban and Troy W. Margrie: Dendrites as Transmitters
22: Kevin M. Boergens, Manuel Berning, Moritz Helmstaedter: Dendritic connectomics
23: Richard B. Dewell, Fabrizio Gabbiani: Linking Dendritic Processing to Computation and Behavior in Invertebrates
24: Daniel Johnston, Andreas Frick, and Nicholas Poolos: Dendrites and Disease
25: Michael Häusser, Nelson Spruston, and Greg Stuart: The Future of Dendrite Research
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Greg Stuart is currently Head of the Eccles Institute of Neuroscience at the Australian National University (ANU), Canberra, Australia. He did his undergraduate at Monash University (Melbourne), before doing a PhD in Neuroscience at the ANU. After his PhD he worked for 5 years at the Max Planck Institute for Medical Research in Heidelberg, Germany. During this time he developed methods for making electrical recordings from dendrites. He is considered a world expert on the physiology of neuronal dendrites and has made a number of seminal contributions to understanding how information is processed by individual nerve cells within the brain.
Nelson Spruston is currently Scientific Program Director and Laboratory Head at the HHMI Janelia Research Campus. He completed his B.Sc. at the University of British Columbia (Vancouver) and his Ph.D. at the Baylor College of Medicine (Houston). He did postdoctoral research at the Max Planck Institute for Medical Research in Heidelberg, Germany. While there, he performed the first dendritic patch-clamp recordings from hippocampal pyramidal neurons. In his own lab (first at Northwestern University and now at Janelia), Spruston studies the role of dendrites in synaptic integration and plasticity. He has also made a number of discoveries concerning the functional properties of a variety of cell types in the hippocampus.
Michael Häusser is Professor of Neuroscience at University College London and a Wellcome Trust Principal Research Fellow. He received his PhD from Oxford University under the supervision of Julian Jack. He subsequently worked with Bert Sakmann at the Max-Planck-Institute for Medical Research in Heidelberg and with Philippe Ascher at the École Normale Supérieure in Paris. He established his own laboratory at UCL in 1997 and became Professor of Neuroscience in 2001. He has made significant contributions to our understanding of the cellular basis of neural computation in the mammalian brain using a combination of experiments and theory, with a special focus on the role of dendrites. His group has helped to pioneer several new approaches for probing the function of single neurons and neural circuits in the intact brain.