The onset of cancer presents one of the fundamental problems in modern biology. This book produces the comprehensive analysis of how particular genetic and environmental causes influence the age of onset. It provides a conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age.
Frank is an evolutionary biologist with a strong mathematics bent. His book grapples with many...issues, offering insights from his mathematical modelling of various steps of tumour progression...One day he may be seen as the pioneer who began the difficult task of building a sturdy foundation for a truly useful mathematical model of cancer development. -- Robert A. Weinberg Nature Frank's forte in the book is his search for the simplicity that is often masked by the complexities of cancer. With his mathematical models in hand, he turns to the details of cancer genetics, carcinogens, and aging and provides novel integrative insights...Dynamics of Cancer emphasizes both the multiscale dynamics of the disease and an approach that synthesizes empirical knowledge with parsimonious, mathematical theory. Frank moves the field forward, narrowing the gap between a tragic disease of everyday life and the Darwinian world of the genome. -- David C. Krakauer Science
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