The Amide Linkage: Structure, Energetics and Applications

About this book

The amide linkage is one of the most fundamental and widespread chemical bonds in nature, and underlies the properties of a vast array of organic molecules, polymers, and materials, including peptides and proteins.

Contents

The Electron Density Distribution of Amides and Related Compounds (C. Breneman & M. Martinov). Origin of the Amide Rotational Barrier (K. Wiberg). The Amide Linkage as a Ligand--Its Properties and the Role of Distortion (A. Greenberg). Studies in Amide Hydrolysis: The Acid, Base, and Water Reactions (R. Brown). The Thermochemistry of Amides (J. Liebman, et al.). Stereospecificity in the alpha-Lactam (Aziridinone) Synthon (R. Hoffman). beta-Lactams: Cyclic Amides of Distinction (A. Bose, et al.). Sterically Hindered Twisted Amides (S. Yamada). Photoelectron Spectroscopy of Amides and Lactams (P. Rademacher). The Role of Amides in the Noncovalent Synthesis of Supramolecular Structures in Solution, at Interfaces, and in Solids (G. Palmore & J. MacDonald). beta-Lactam Antibacterial Agents: Computational Chemistry Investigations (D. Boyd). Three-Dimensional Design of Enzyme Inhibitors with Heterocyclic Amide Bond Mimics (R. Bohacek & W. Shakespeare). Ab Initio Conformational Analysis of Protein Subunits: A Case Study of the Serine Diamide Model (A. Perczel & I. Csizmadia). Gas-Phase Ion Chemistry of Amides, Peptides, and Proteins (C. Cassady). beta-Sheet Interactions Between Proteins (S. Maitra & J. Nowick). Head-to-Tail Cyclic Peptides and Cyclic Peptide Libraries (A. Spatola & P. Romanovskis). From Crystal Structures of Oligopeptides to Protein Folding. The Importance of Peptide Bond-Side Chain Hyperconjugation (A. Cieplak). Role of the Peptide Bond in Protein Structure and Folding (N. Kallenbach, et al.). Index.

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