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By: John S Torday(Author), Virender K Rehan(Author)
By focusing on the cellular mechanisms that underlie ontogeny, phylogeny and regeneration of complex physiologic traits, Evolution, the Logic of Biology demonstrates the use of homeostasis, the fundamental principle of physiology and medicine, as the unifying mechanism for evolution as all of biology. The homeostasis principle can be used to understand how environmental stressors have affected physiologic mechanisms to generate condition-specific novelty through cellular mechanisms.
Evolution, the Logic of Biology allows the reader to understand the vertebrate life-cycle as an intergenerational continuum in support of effective, on-going environmental adaptation. By understanding the principles of physiology from their fundamental unicellular origins, culminating in modern-day metazoans, the reader as student, researcher or practitioner will be encouraged to think in terms of the prevention of disease, rather than in the treatment of disease as the eradication of symptoms.
By tracing the ontogeny and phylogeny of this and other phenotypic homologies, one can perceive and understand how complex physiologic traits have mechanistically evolved from their simpler ancestral and developmental origins as cellular structures and functions, providing a logic of biology for the first time.
Evolution, the Logic of Biology will be an invaluable resource for graduate students and researchers studying evolutionary development, medicine and biology, anthropology, comparative and developmental biology, genetics and genomics, and physiology.
1. Introduction to Evolution, the Logic of Biology
2. On the Fractal Nature of Evolution
3. The Historic Perspective on Paracrinology and Evolution as Lead-ins to a Systems Biology Approach
4. Evolution of ADRP, or Oh the Places You'll Go - Theodore Geissel, AKA Dr. Seuss
5. Evolutionary Ontology and Epistemology
6. Calcium-Lipid Epistasis- Ouroboros
7. The Lung Alveolar Lipofibroblast: An Evolutionary Strategy Against Neonatal Hyperoxic Lung Injury
9. Cell Signaling is All of Biology
10. Information + Negentropy + Homeostasis= Evolution
11. Vertical Integration of Cytoskeletal Function from Yeast to Man
12. Yet another bite of the evolutionary apple
13. On Eliminating the Subjectivity from Biology- Predictions
14. The Predictive Value of the Cellular Approach to Evolution
15. Homeostasis as the Mechanism of Evolution
16. On the Evolution of Development
17. A Central Theory of Biology
18. Implications of Evolutionary Physiology for Astrobiology
19. Pleiotropy, the Mechanism for Evolutionary Novelty
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