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This book provides an overview of the utility of force microscopy in biology and medicine, offering the reader some perspective on the power and scope of this new scientific tool. Included is a discussion of the development of the photonic force microscope, and the use of force microscopy in combination with EM, electrophysiology, and biochemistry. These have already had a great impact in biology, and we are just beginning to realize the enormous benefits of force microscopy to both the biological and medical fields.
Preface.Contributors.Chapter 1. Porosome: The Universal Secretory Machinery in Cells (Bhanu P. Jena).Chapter 2. Molecular Mechanism of SNARE-Induced Membrane Fusion (Bhanu P. Jena).Chapter 3. Molecular Mechanism of Secretory Vesicle Content Expulsion During Cell Secretion (Bhanu P. Jena).Chapter 4. Fusion Pores in Growth-Hormone-Secreting Cells of the Pituitary Gland: An AFM Study (Lloyd L. Anderson and Bhanu P. Jena).Chapter 5. Properties of Microbial Cell Surfaces Examined by Atomic Force Microscopy (Yves F. Dufrene).Chapter 6. Scanning Probe Microscopy of Plant Cell Wall and Its Constituents (Ksenija Radotic, Miodrag Micic, and Milorad Jeremic).Chapter 7. Cellular Interactions of Nano Drug Delivery Systems (Rangaramanujam M. Kannan, Omathanu Pillai Perumal, and Sujatha Kannan).Chapter 8. Adapting AFM Techniques for Studies on Living Cells (J. K. Heinrich Horber)Chapter 9. Intermolecular Forces of Leukocyte Adhesion Molecules (Xiaohui Zhang and Vincent T. Moy).Chapter 10. Mechanisms of Avidity Modulation in Leukocyte Adhesion Studied by AFM (Ewa P. Wojcikiewicz and Vincent T. Moy).Chapter 11. Resolving the Thickness and Micromechanical Properties of Lipid Bilayers and Vesicles Using AFM (Guangzhao Mao and Xuemei Liang).Chapter 12. Imaging Soft Surfaces by SFM (Andreas Janke and Tilo Pompe).Chapter 13. High-Speed Atomic Force Microscopy of Biomolecules in Motion (Tilman E. Schaffer).Chapter 14. Atomic Force Microscopy in Cytogenetics (S. Thalhammer and W. M. Heckl).Chapter 15. Atomic Force Microscopy in the Study of Macromolecular Interactions in Hemostasis and Thrombosis: Utility for Investigation of the Antiphospholipid Syndrome (William J. Montigny, Anthony S. Quinn, Xiao-Xuan Wu, Edwin G. Bovill, Jacob H. Rand, and Douglas J. Taatjes).Index
BHANU P. JENA, PHD, DSc, is the George E. Palade University Professor and Distinguished Professor of Physiology at Wayne State University School of Medicine, Detroit, Michigan. In addition, Dr. Jena is Director of the University's NanoBioScience Institute. J. K. HEINRICH HORBER, PhD, is Professor in the Department of Physics at University of Bristol, Bristol, UK.