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How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks?
With its unique integration of genetics and molecular biology, Genetic Analysis probes fascinating questions such as these, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, Genetic Analysis goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the genetic structure of natural populations follows, before the interaction of genes during suppression and epistasis, how we study gene networks, and personalized genomics are considered.
Drawing on the latest experimental tools, including microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research, without losing clarity of explanation and insight.
We are in an age where, despite knowing so much about biological systems, we are just beginning to realise how much more there is still to understand. Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding.
New to this edition:
- A new chapter in Unit I, Genomes, Chromosomes, and Epigenetics, places the genome into the context of chromosome structure, with discussion of epigenetics and ENCODE.
- Unit II has been substantially revised in light of the availability of whole genomes, with examples of exome sequencing and genome-wide mutant screens thoroughly discussed.
- Unit III comprises three new chapters dealing with genome-wide association studies, complex traits, and the genetic structure of natural populations.
- Unit IV now includes a discussion of genome-wide analysis of gene interactions in yeast, as well as a new chapter focusing on the relationship between genotype and phenotype in the context of personal genomics.
- Coverage of human genetics has been expanded with further examples from human genetic diversity and disease, reflecting the enormous advances made in these areas.
- Further reading sections are now included at the end of chapters, to offer guidance to those wishing to explore a topic in more depth.
- Study questions, designed to be used alongside chapters and to offer different levels of challenge, have been added to the Online Resource Centre.
Unit I Genes, Chromosomes, and Genomes
1: The Logic of Genetic Analysis
2: Model Organisms and Their Genomes
3: Genomes, Chromosomes, and Epigenetics
Unit II Genes and Mutations
4: Identifying and Classifying Mutants
5: Connecting a Phenotype to a DNA Sequence
6: Finding Mutant Phenotypes for Cloned Genes
7: Genome-wide Mutant Screens
Unit III Genes and Natural Variation
8: Genome-wide Associations
9: Genetic Analysis of Complex Traits
10: Genetic Analysis Using Natural Variation
Unit IV Gene Interactions
11: Using One Gene to Identify Functionally Related Genes
12: Epistasis and Genetic Pathways
13: Pathways, Networks, and Systems
14: Genes, Systems, and Phenotypes
Reviews from the previous edition:
"It is, in many ways, the book I have been looking for since I started to teach this course 15 years ago: a book that teaches methods of genetic analysis and is suitable for a senior-level course."
– Dr Steve Mount, Department of Cell Biology and Molecular Genetics, University of Maryland, USA
"I love this text. I have not seen a text with as much current information on the most important aspects of genetics and genomics today."
– Professor Christine Rushlow, Department of Biology, New York University, USA
"It is an innovative effort to present standard genetic approaches in the context of recent genome-wide approaches."
– Professor Stephen H. Munroe, Biological Sciences, Marquette University, USA
"It is refreshing to see the focus move away from the detail of molecular mechanism towards understanding and scientific investigation. [...] Philip Meneely makes a concerted effort to tie the key concepts derived from model systems to an understanding of human medical genetics, which works well and will be appreciated by students."
– The Society for General Microbiology