How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks?
With its unique integration of genetics and molecular biology, Genetic Analysis probes fascinating questions such as these, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, Genetic Analysis goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the genetic structure of natural populations follows, before the interaction of genes during suppression and epistasis, how we study gene networks, and personalized genomics are considered.
Drawing on the latest experimental tools, including CRISPR-Cas9 genome editing, microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research, without losing its clarity of explanation and insight.
We are in an age where, despite knowing so much about biological systems, we are just beginning to realise how much more there is still to understand. Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding.
1: The Basis for Genetic Analysis
2: Genomes, Chromosomes, and Epigenetics
3: Model Organisms and Their Genomes
4: Identifying and Classifying Mutants
5: Connecting Phenotypes with DNA Sequences
6: Mutant Phenotypes and Gene Activity
7: Reverse Genetics: Editing genes in yeast and mice
8: Genome Editing
9: Genome-Wide Mutant Screens
10: Gene Interactions: Suppressors and Synthetic Enhancers
11: Epistasis and Genetic Pathways
12: Pathways, Networks, and Phenotypes
Reviews of previous editions:
"An excellent example of a modern textbook, Genetic Analysis is a readable and stimulating introduction to this rapidly developing topic [...] [It] will earn its place on a biology or genetics student's bookshelf."
– David Slingsby, The Biologist
"It is, in many ways, the book I have been looking for since I started to teach this course 15 years ago: a book that teaches methods of genetic analysis and is suitable for a senior-level course."
– Dr Steve Mount, Department of Cell Biology and Molecular Genetics, University of Maryland, USA
"I love this text. I have not seen a text with as much current information on the most important aspects of genetics and genomics today."
– Professor Christine Rushlow, Department of Biology, New York University, USA
"It is an innovative effort to present standard genetic approaches in the context of recent genome-wide approaches."
– Professor Stephen H. Munroe, Biological Sciences, Marquette University, USA
"It is refreshing to see the focus move away from the detail of molecular mechanism towards understanding and scientific investigation. [...] Philip Meneely makes a concerted effort to tie the key concepts derived from model systems to an understanding of human medical genetics, which works well and will be appreciated by students."
– The Society for General Microbiology
"This textbook is one of the few that can be used for an advanced undergrad/beginning grad level course. It is ideal for a class that uses the primary literature as a major part of the reading and discussion in the class. "
– Dr Brian Condie, Department of Genetics, University of Georgia