307 pages, 87 colour photos and colour illustrations, 15 colour & b/w tables
Sharks belong to the oldest vertebrate species that possess immune systems similar to that of mammals, thus it is a great model species to study the fundamentals of the mammalian immune system. Analysis of sharks might also reveal insights into the other species' immune systems. Immunobiology of the Shark describes the cellular, genetic, and molecular details of immune systems in sharks. It describes immunity in the sharks themselves and the evolution of immune systems in more derived species. Written by global experts, Immunobiology of the Shark will appeal to students and experienced researchers in comparative immunology and related scientific fields.
"Immunobiology of the Shark is a comprehensive resource for immunologists, evolutionary biologists and other scientists interested in understanding how the integration of cellular and humoral processes has created a highly effective survival mechanism. This volume incorporates a rich, diverse literature into a well-reasoned, comprehensive package that will permit the reader to understand topics as diverse as the placement of the shark in phylogeny, the uniqueness of its physiology and the mechanisms regulating how the rearranging immune genes make the somatic immune cell a selectable unit. An exceptional number of findings are described that are of immediate relevance to understanding immune regulation in the far more widely studied immune systems of man and mouse. [...] If one message rings true, it is that alternative animal model systems, such as sharks and their relatives are critical to our understanding of the scope of evolutionary change and the mechanisms underlying variation. Immunobiology of the Shark will prove to be an invaluable resource as well as guide for future investigations of how the systematic integration of pathways and processes give rise to successful biological adaptations."
– Gary W. Litman, PhD, Distinguished University Professor, University of South Florida, Tampa, USA
The Diversity and Natural History of Chondrichthyan Fishes; Gregor M. Cailliet and David A. Ebert
Athena and the Evolution of Adaptive Immunity; Helen Dooley
Shark Reproduction, Immune System Development and Maturation: A Review; Lynn L. Rumfelt
Sites of Immune Cell Production in Elasmobranch Fishes: Lymphomyeloid Tissues and Organs; Carl A. Luer, Catherine J. Walsh, and A.B. Bodine
Elasmobranch Blood Cells; Ashley N. Haines and Jill E. Arnold
Leukocyte Function in Elasmobranch Species: Phagocytosis, Chemotaxis, and Cytotoxicity; Catherine J. Walsh and Carl A. Luer
Cytokines of Cartilaginous Fish; C.J. Secombes, J. Zou, and S. Bird
Shark Complement: Genes, Proteins and Function; Sylvia L. Smith and Masaru Nonaka
MHC Molecules of Cartilaginous Fishes; Simona Bartl and Masaru Nonaka
Considering V(D)J Recombination in the Shark; Ellen Hsu
Shark Immunoglobulin Light Chains; Michael F. Criscitiello
Shark T-Cell Receptors; Michael F. Criscitiello
The Shark-Family (Cartilaginous Fish) Immunogenome; Byrappa Venkatesh and Yuko Ohta
In Vitro Culture of Elasmobranch Cells; Catherine J. Walsh and Carl A. Luer
Antimicrobial Molecules of Sharks and Other Elasmobranchs: A Review; Nichole Hinds Vaughan and Sylvia L. Smith
Shark-Derived Immunomodulators; Liza Merly and Sylvia L. Smith
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