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Humanity's physical design flaws have long been apparent – we get hemorrhoids and impacted wisdom teeth, for instance – but do the imperfections extend down to the level of our genes? Inside the Human Genome is the first book to examine the philosophical question of why, from the perspectives of biochemistry and molecular genetics, flaws exist in the biological world. Distinguished evolutionary geneticist John Avise offers a panoramic yet penetrating exploration of the many gross deficiencies in human DNA – ranging from mutational defects to built-in design faults – while at the same time offering a comprehensive treatment of recent findings about the human genome. The author shows that the overwhelming scientific evidence for genomic imperfection provides a compelling counterargument to intelligent design. He also develops a case that theologians should welcome rather than disavow these discoveries. The evolutionary sciences can help mainstream religions escape the shackles of Intelligent Design, and thereby return religion to its rightful realm – not as the secular interpreter of the biological minutiae of our physical existence, but rather as a respectable philosophical counselor on grander matters of ultimate concern.
– The Journal of Heredity
"A wonderful trip through the workings – and non-workings! – of the human genome. The author opens the door to a view of life that is exciting for those who love science and theologically stimulating for those with religious beliefs. Everyone who cares about human nature should read this book."
– Michael Ruse, Lucyle T. Werkmeister Professor of Philosophy, Florida State University, and author of Darwinism and its Discontents
1: The Eternal Paradox
2: Fallible Design: Protein-Coding DNA Sequences
3: Baroque Design: Gratuitous Genomic Complexity
4: Wasteful Design: Repetitive DNA Elements
5: Intelligent or Non-Intelligent Design?
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John C. Avise is Distinguished Professor of Ecology and Evolutionary Biology, at the University of California, Irvine, and an elected member of both the National Academy of Sciences and the American Academy of Arts and Sciences.