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From the author of the acclaimed The Epigenetics Revolution ('A book that would have had Darwin swooning' – Guardian) comes another thrilling exploration of the cutting edge of human science. For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions – 98% of the human genome – were dismissed as 'junk'. But in recent years researchers have discovered that variations in this 'junk' DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them.
Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself – and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.
Nessa Carey has a PhD in virology from the University of Edinburgh and worked in the biotech and pharma industry for thirteen years. She is a Visiting Professor at Imperial College, London. Her previous book, The Epigenetics Revolution, was published by Icon Books in 2011. and described as a 'book that would have had Darwin swooning – anyone seriously interested in who we are and how we function should read this.'
"A cutting-edge, exhaustive guide to the rapidly changing, ever-more mysterious genome"
– New Scientist