837 pages, colour & b/w photos, colour illustrations
Long considered the quintessential molecular biology textbook, for decades Lewin's Genes has provided the most modern presentation to this transformative and dynamic science. Now in its twelfth edition, this classic text continues to lead with new information and cutting-edge developments, covering gene structure, sequencing, organization, and expression. Leading scientists provide revisions and updates in their respective areas of study offering readers current research and relevant information on the rapidly changing subjects in molecular biology. No other text offers a broader understanding of this exciting and vital science or does so with higher quality art and illustrations. Lewin's Genes XII continues to be the clear choice for molecular biology and genetics.
Part 1 Genes and Chromosomes
Chapter 1 Genes Are DNA and Encode RNAs and Polypeptides
Chapter 2 Methods in Molecular Biology and Genetic Engineering
Chapter 3 The Interrupted Gene
Chapter 4 The Content of the Genome
Chapter 5 Genome Sequences and Evolution
Chapter 6 Clusters and Repeats
Chapter 7 Chromosomes
Chapter 8 Chromatin
Part 2 DNA Replication and Recombination
Chapter 9 Replication Is Connected to the Cell Cycle
Chapter 10 The Replicon: Initiation of Replication
Chapter 11 DNA Replication
Chapter 12 Extrachromosomal Replicons
Chapter 13 Homologous and Site-Specific Recombination
Chapter 14 Repair Systems
Chapter 15 Transposable Elements and Retroviruses
Chapter 16 Somatic DNA Recombination and Hypermutation in the Immune System
Part 3 Transcription and Posttranscriptional Mechanisms
Chapter 17 Prokaryotic Transcription
Chapter 18 Eukaryotic Transcription
Chapter 19 RNA Splicing and Processing
Chapter 20 mRNA Stability and Localization
Chapter 21 Catalytic RNA
Chapter 22 Translation
Chapter 23 Using the Genetic Code
Part 4 Gene Regulation
Chapter 24 The Operon
Chapter 25 Phage Strategies
Chapter 26 Eukaryotic Transcription Regulation
Chapter 27 Epigenetics I
Chapter 28 Epigenetics II
Chapter 29 Noncoding RNA
Chapter 30 Regulatory RNA
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Jocelyn E. Krebs has been a member of the Department of Biological Sciences at the University of Alaska Anchorage since 2000. She received her B.A. in Biological Sciences from Bard College in 1991 and her PhD in Molecular and Cell Biology from the University of California Berkeley in 1997. Her research focuses on the mechanisms by which DNA transactions such as transcription and repair are accomplished in the context of chromatin. Her teaching interests are in Molecular Biology (taught at the undergraduate, graduate, and first-year medical school levels), as well as the Molecular Biology of Cancer.
Elliott S. Goldstein earned his B.S. in Biology from the University of Hartford (Connecticut) and his Ph.D. in Genetics from the University of Minnesota, Department of Genetics and Cell Biology. Following this, he was awarded an N.I.H. Postdoctoral Fellowship to work with Dr. Sheldon Penman at the Massachusetts Institute of Technology. Leaving Boston, he joined the faculty at Arizona State University in Tempe, where he is an Associate Professor in the Cellular, Molecular and Biosciences program in the School of Life Sciences, and in the Honors Disciplinary Program. His research interests are in the area of molecular and developmental genetics of early embryogenesis in Drosophila melanogaster. In recent years, he has focused on the Drosophila counterparts of the human proto-oncogenes jun and fos. His primary teaching responsibilities are in the undergraduate General Genetics course as well as the graduate level Molecular Genetics course.
Stephen T. Kilpatrick is an Associate Professor of Biology at the University of Pittsburgh at Johnstown (UPJ). He received a B.S. in Biology for Eastern College (now Eastern University) and a PhD from the Program in Ecology and Evolutionary Biology at Brown University. His research an teaching interests are in evolutionary molecular genetics. UPJ is an undergraduate degree-granting campus of the University of Pittsburgh, and Dr. Kilpatrick regularly teaches undergraduate courses in majors introductory biology, genetics, evolution, molecular genetics, and biostatistics. Prior to coauthoring the Second Edition of Lewin's Essential Genes, Dr. Kilpatrick has co-authored the test banks for the first edition and for Lewin's Genes VIII and Genes IX. He has also authored ancillaries and pedagogical materials for several introductory non-majors and majors biology and genetics textbooks.