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Medicinal Chemistry of Bioactive Natural Products: Reviews and Perspectives

By: Xiao-Tian Liang(Editor), Wei-Shuo Fang(Editor)

460 pages, illustrations

John Wiley & Sons

Hardback | Apr 2006 | #210515 | ISBN: 0471660078
Availability: Usually dispatched within 4 days Details
NHBS Price: £83.50 $108 / €96 approx

About this book

Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies – developed for natural products – with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.

Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, Medicinal Chemistry of Bioactive Natural Products serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research.

Enhanced by examples with updated research results, the discussion covers such topics as:
- The chemistry and biology of epothilones
- Vancomycin and other glycopeptide antibiotic derivates
- Antitumor and other related activities of Taxol and its analogs
- The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)
- Huperzine A: A natural drug for the treatment of Alzheimer's disease
- The medicinal chemistry of ginkgolides from Ginkgo biloba
- Recent progress in Calophyllum coumarins as potent anti-HIV agents
- Plant-derived anti-HIV agents and analogs
- Chemical synthesis of annonaceous acetogenins and their structurally modified mimics

"[...] an in-depth resource for anyone concerned about natural products and their application in medicine [...] it provides concise information that is difficult to find in a compact format elsewhere."
- Clinical Chemistry, January 2007

"[...] I can imagine this book being used in an interdisciplinary graduate course [...] [or] as a reference text."
- Journal of the American Chemical Society, September 13, 2006

"The authors are to be commended on the excellent blending of chemical, biological, and pharmacologic data [...] highly recommended to all with an interest in medicinal natural products chemistry."
- Journal of Medicinal Chemistry, June 1, 2006



1 The Chemistry and Biology of Epothilones—Lead Structures for the Discovery of Improved Microtubule Inhibitors (Karl-Heinz Altmann)
2 The Chemistry and Biology of Vancomycin and Other Glycopeptide Antibiotic Derivatives (Roderich D. Su¨ssmuth)
3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogs (Wei-Shuo Fang, Qi-Cheng Fang, and Xiao-Tian Liang)
4 The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer’s Disease (Da-Yuan Zhu, Chang-Heng Tan, and Yi-Ming Li)
5 Qinghaosu (Artemisinin)—A Fantastic Antimalarial Drug from a Traditional Chinese Medicine (Ying Li, Hao Huang, and Yu-Lin Wu)
6 Progress of Studies on the Natural Cembranoids from the Soft Coral Species of Sarcophyton Genus (Yulin Li, Lizeng Peng, and Tao Zhang)
7 Medicinal Chemistry of Ginkgolides from Ginkgo biloba (Kristian Strømgaard)
8 Recent Progress in Calophyllum Coumarins as Potent Anti-HIV Agents (Lin Wang, Tao Ma, and Gang Liu)
9 Recent Progress and Prospects on Plant-Derived Anti-HIV Agents and Analogs (Donglei Yu and Kuo-Hsiung Lee)
10 Recent Progress on the Chemical Synthesis of Annonaceous Acetogenins and Their Structurally Modified Mimics (Tai-Shan Hu, Yu-Lin Wu, and Zhu-Jun Yao)


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Xiao-Tian Liang received his BS degree from the National Central University (China) in 1946 and his PhD degree from the University of Washington at Seattle (USA) in 1951. After postdoctoral work at Harvard University, he joined the faculty of the Institute of Materia Medica, Chinese Academy of Medical Sciences. In 1980, he was elected as an Academician of Academia Sinica (Chinese Academy of Sciences) and has served on the advisory editorial boards of Tetrahedron and Tetrahedron Letters, among other scientific journals. He coauthored more than 300 scientific papers and reviews, and has written or edited more than ten books.

Wei-Shuo Fang graduated from Beijing Medical University, and obtained his PhD degree from Peking Union Medical College (PUMC) in 1997. After postdoctoral training in the US, he joined the faculty of the Institute of Materia Medica, Chinese Academy of Medical Sciences & PUMC. He has conducted visiting study in the University of Illinois at Urbana-Champaign and coauthored more than thirty articles in peer-reviewed journals.

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