About this book
The concept of molecular machines in biology has transformed the medical field in a profound way. Many essential processes that occur in the cell, including transcription, translation, protein folding and protein degradation, are all carried out by molecular machines. This volume focuses on important molecular machines whose architecture is known and whose functional principles have been established by tools of biophysical imaging (X-ray crystallography and cryo-electron microscopy) and fluorescence probing (single-molecule FRET). This edited volume includes contributions from prominent scientists and researchers who understand and have explored the structure and functions of these machines. This book is essential for students and professionals in the medical field who want to learn more about molecular machines.
1. Single-molecule FRET: technique and applications to the studies of molecular machines Xinghua Shi and Taekjip Ha
2. Visualization of molecular machines by cryo-electron microscopy Joachim Frank
3. Statistical mechanical treatment of molecular machines Debashish Chowdhury
4. Investigation of molecular machines by normal mode analysis Karunesh Arora and Charles L. Brooks, III
5. Structure, function, and evolution of archaeo-eukaryotic RNA polymerases - gatekeepers of the genome Finn Werner and Dina Grohmann
6. Single-molecule fluorescence resonance energy transfer investigations of ribosome-catalyzed protein synthesis Daniel D. MacDougall, Jingyi Fei and Ruben L. Gonzalez, Jr
7. Structure and dynamics of the ribosome as revealed by cryo-electron microscopy Xabier Agirrezabala and Mikel Valle
8. Viewing the mechanisms of translation through the computational microscope James Gumbart, Eduard Schreiner, Leonardo G. Trabuco, Kwok-Yan Chan and Klaus Schulten
9. The ribosome as a Brownian ratchet machine Alexander S. Spirin and Alexei V. Finkelstein
10. The GroEL/GroES chaperonin machine Arthur L. Horwich and Helen R. Saibil
11. ATP synthase - a paradigmatic molecular machine Thomas Meier, Jose Faraldo-Gomez and Michael Borsch
12. ATP-dependent proteases Sucharita Bhattacharyya, Shameika R. Wilmington and Andreas Matouschek.
Dr Joachim Frank is a Howard Hughes Medical Institute Investigator, Professor of Biochemistry and Molecular Biophysics and Professor of Biological Sciences at Columbia University. He has received many awards for his research, including, with David DeRosier, the Elizabeth Robert Cole Award of the Biophysics Society. He has published more than 200 peer-reviewed articles, written numerous book chapters and authored or edited five books, including "Electron Crystallography of Biological Macromolecules", edited with Kenneth Downing, David DeRosier and Wah Chiu (2007) and "Electron Tomography" (Second edition, 2010).