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The prediction of protein structure and function is an increasingly important discipline used by the pharmaceutical industry to help researchers select and understand drug targets and refine drug candidates. This book presents a comprehensive overview of methods for prediction of protein structure or function, with the emphasis on their availability and possibilities for their combined use.
List of Contributors. Preface. 1 The Basics of Protein Sequence Analysis (Katarzyna H. Kaminska, Kaja Milanowska and Janusz M. Bujnicki). 2 First Steps of Protein Structure Prediction (Karolina Majorek, ukasz Koz owski, Marcin J akalski and Janusz M. Bujnicki). 3 Automated Prediction of Protein Function from Sequence (Meghana Chitale, Troy Hawkins and Daisuke Kihara). 4 Template Based Prediction of Three-dimensional Protein Structures: Fold Recognition and Comparative Modeling (Jan Kosi-nski, Karolina L. Tkaczuk, Joanna M. Kasprzak and Janusz M. Bujnicki). 5 Template-free Predictions of Three-dimensional Protein Structures: From First Principles to Knowledge-based Potentials (Dominik Gront, Dorota Latek, Mateusz Kurcinski and Andrzej Kolinski). 6 Quality Assessment of Protein Models (Bj orn Wallner and Arne Elofsson). 7 Prediction of Molecular Interactions from 3D-structures: From Small Ligands to Large Protein Complexes (Kengo Kinoshita, Hidetoshi Kono and Kei Yura). 8 Structure-based Prediction of Enzymes and Their Active Sites (James W. Torrance and Janet M. Thornton). 9 The Prediction of Macromolecular Complexes by Docking (Sjoerd J. de Vries, Marc van Dijk and Alexandre M.J.J. Bonvin). 10 Protein Function Prediction via Analysis of Interactomes (Elena Nabieva and Mona Singh). 11 Integrating Prediction of Structure, Function, and Interactions (Michael Tress, Janusz M. Bujnicki, Gonzalo Lopez and Alfonso Valencia). Index.
Professor Bujnicki is head of the Laboratory of Bioinformatics and Protein Engineering at the International Institute of Molecular and Cell Biology, Warsaw, Poland. He is the editor of "Practical Bioinformatics" (Springer-Verlag, 2004).