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Academic & Professional Books  Organismal to Molecular Biology  Biochemistry & Molecular Biology

Regeneration

By: Kenneth D Poss(Editor), Donald T Fox(Editor)
451 pages, 85 colour & 1 b/w illustrations
Regeneration
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  • Regeneration ISBN: 9781621824091 Hardback Mar 2022 Out of stock: Usually dispatched within 1-2 weeks
    £83.99
    #259421
Price: £83.99
About this book Contents Customer reviews Related titles

About this book

The formation of new cells, tissues, and organs enables animals to recover from day-to-day wear and tear, injury, and disease. Some animals, such as sea stars, planarians, and lizards, can regenerate entire limbs and other body parts. But in mammals, including humans, some tissues (e.g., heart muscle) are more resistant to regeneration.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology explores the biological basis of regeneration in diverse animal species and how this knowledge can be applied therapeutically in humans. The contributors discuss the dramatic molecular and cellular changes that occur when a regeneration program is initiated, the progenitor cells and morphogenic signals involved, the formation of a blastema, the roles of reprogramming and polyploidy, the diversity of cell fates, the integration of new structures with existing body parts, and our current understanding of why some structures are more resistant to regeneration than others. The importance of technologies (e.g., single-cell RNA-seq) that have been instrumental in deciphering various aspects of regeneration in recent years is emphasized throughout.

Examples of regeneration in flatworms, Hydra, insects, salamanders, frogs, fish, and mammals are described. Several chapters are also devoted to regeneration in specific human organs – the skin, retina, heart, lung, pancreas, liver, skeletal muscle, and intestine – and examine possibilities for therapeutically replacing injured or diseased structures and for managing age-related declines in function. This volume is therefore essential reading for molecular, cell, and developmental biologists studying regeneration in animals, as well as for all interested in the development of regenerative therapies for clinical application.

Contents

Preface

- Positional Information and Stem Cells Combine to Result in Planarian Regeneration / Peter W. Reddien
- Cellular, Metabolic, and Developmental Dimensions of Whole-Body Regeneration in Hydra / Matthias Christian Vogg, Wanda Buzgariu, Nenad Slavko Suknovic, and Brigitte Galliot
- Imaginal Disc Regeneration: Something Old, Something New / Melanie I. Worley and Iswar K. Hariharan
- Insect Gut Regeneration / Peng Zhang and Bruce A. Edgar
- Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration / Ivonne Sehring and Gilbert Weidinger
- Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb / Leo Otsuki and Elly M. Tanaka
- Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook / Devon Davidian and Michael Levin
- Innate Mechanisms of Heart Regeneration / Hui-Min Yin, C. Geoffrey Burns, and Caroline E. Burns
- Comparative Biology of Vertebrate Retinal Regeneration: Restoration of Vision through Cellular Reprogramming / Levi Todd and Thomas A. Reh
- Pancreatic ß-Cell Development and Regeneration / Natanya Kerper, Sudipta Ashe, and Matthias Hebrok
- Hematopoietic Stem Cells and Regeneration / Mitch Biermann and Tannishtha Reya
- All for One and One for All: Regenerating Skeletal Muscle / Sajedah M. Hindi and Douglas P. Millay
- Genetic and Cellular Contributions to Liver Regeneration / Roger Liang, Yu-Hsuan Lin, and Hao Zhu
- Building and Maintaining the Skin / Ya-Chieh Hsu and Elaine Fuchs
- Mammalian Digit Tip Regeneration: Moving from Phenomenon to Molecular Mechanism / Gemma L. Johnson and Jessica A. Lehoczky
- Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration / Brisa Palikuqi, Jérémie Rispal, and Ophir Klein
- Lung Regeneration: Cells, Models, and Mechanisms / Arvind Konkimalla, Aleksandra Tata, and Purushothama Rao Tata
- Axon Regeneration: A Subcellular Extension in Multiple Dimensions / Carla C. Winter, Zhigang He, and Anne Jacobi
- The Diverse Manifestations of Regeneration and Why We Need to Study Them / Vidyanand Sasidharan and Alejandro Sánchez Alvarado
- Polyploidy in Tissue Repair and Regeneration / Erin C. Bailey, Sara Kobielski, John Park, and Vicki P. Losick
- Somatic Lineage Reprogramming / Hannah Shelby, Tara Shelby, and Marius Wernig
- Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging /Thomas A. Rando and D. Leanne Jones

Index

 

Customer Reviews

By: Kenneth D Poss(Editor), Donald T Fox(Editor)
451 pages, 85 colour & 1 b/w illustrations
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