All Shops

Go to British Wildlife

6 issues per year 84 pages per issue Subscription only

British Wildlife is the leading natural history magazine in the UK, providing essential reading for both enthusiast and professional naturalists and wildlife conservationists. Published six times a year, British Wildlife bridges the gap between popular writing and scientific literature through a combination of long-form articles, regular columns and reports, book reviews and letters.

Subscriptions from £25 per year

Conservation Land Management

4 issues per year 44 pages per issue Subscription only

Conservation Land Management (CLM) is a quarterly magazine that is widely regarded as essential reading for all who are involved in land management for nature conservation, across the British Isles. CLM includes long-form articles, events listings, publication reviews, new product information and updates, reports of conferences and letters.

Subscriptions from £18 per year
Academic & Professional Books  Environmental & Social Studies  Economics, Politics & Policy  Science & Technology  Biotechnology & the Environment

Replacing Animal Models A Practical Guide to Creating and Using Culture-Based Biomimetic Alternatives

Handbook / Manual
Edited By: Jamie Davies
Replacing Animal Models
Click to have a closer look
Select version
  • Replacing Animal Models ISBN: 9780470974254 Hardback Apr 2012 Usually dispatched within 4 days
    £60.00
    #197329
Selected version: £60.00
About this book Contents Customer reviews Related titles

About this book

Over the last decade, in vitro models have become more sophisticated and are at a stage where they can provide an effective alternative to in vivo experiments. Replacing Animal Models provides scientists and technicians with a practical, integrated guide to developing culture-based alternatives to in vivo experiments.

The book is neither political nor polemical: it is technical, illustrating by example how alternatives can be developed and used and providing useful advice on developing others. After looking at the reasons for and potential benefits of alternatives to animal experiments, the book covers a range of methods and examples emphasising the design considerations that went into each system. The chapters also include 'case studies' that illustrate the ways in which culture models can be used to answer a range of important biological questions of direct relevance to human development, physiology, disease and healing.

The thesis of this book is not that all animal experimentation can be replaced, now or in the near future, by equally effective or superior alternatives. Rather, the premise is that there is substantial opportunity, here and now, to do some common types of experiment better in vitro than in vivo, and that doing so will result in both scientific and ethical gains.

Contents

Contributors, vii
Preface, xi

Section 1 Introductory Material
1 Potential Advantages of Using Biomimetic Alternatives, 3
2 Overview of Biomimetic Alternatives, 13

Section 2 Culture Methods
3 Pancreatic Islets, 23
4 Endometrial Organoid Culture, 35
5 Modelling Lymphatic and Blood Capillary Patterning, 45
6 Precision-cut Lung Slices (PCLS), 57
7 Human Colon Tissue in Organ Culture, 69
8 Fetal Organ Culture, 81
9 Design of a Mechanical Loading Device to Culture Intact Bovine Spinal Motion Segments under Multiaxial Motion, 89
10 Magnetic Assembly of Tissue Surrogates, 107
11 Assembly of Renal Tissues by Cellular Self-organization, 115

Section 3 Case Studies of Use
12 Hierarchical Screening of Pathways: Using Cell and Organ Cultures to Reduce use of Transgenic Mice, 125
13 Lung Organoid Culture to Study Responses to Viruses, 137
14 Organ-cultured Human Skin for the Study of Epithelial Cell Invasion of Stroma, 151
15 Organotypic Mandibular Cultures for the Study of Inflammatory Bone Pathology, 159
16 Three-dimensional, High-density and Tissue Engineered Culture Models of Articular Cartilage, 167
17 Concluding Remarks, 193

Appendix 1 Sources of funding for development of culture-based alternatives, 195
Appendix 2 Databases and web-based discussions relevant to development of alternatives, 197
Index, 199

Customer Reviews

Handbook / Manual
Edited By: Jamie Davies
Current promotions
Best of Winter 2018Harper CollinsOrder your free copy of our 2018 equipment catalogueBritish Wildlife