This book is a reprint of a special issue published online in open access journal Toxins. This book covers recent developments in snake venom metalloproteinase structure, function and clinical implications. It includes a historical retrospective of the discovery of Snake Venom Metalloproteinases (SVMPs) and early insights into their biochemical mechanisms and how they function in envenomation. The individual articles review SVMP structure, pathologies associated with SVMPs activities, mechanism of action, evolution and orthologs, SVMP processing and disintegrins, and potential clinical applications of SVMP scaffolds.