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The origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley's rigorous scientific thought, elegant experimental design, ingenious analysis, and beautiful writing.
This book provides the first annotated edition of these papers, offering essential background on everything, from terminology, equations, and electronics, to the greater historical and scientific context surrounding the work. The original journal pages are displayed opposite detailed notes explaining content, process, and background, with copies of the figures replotted according to modern conventions. Indispensable for scientists, teachers, and trainees alike, The Annotated Hodgkin & Huxley makes an essential body of knowledge – and an unparalleled approach to research – accessible to a new generation of readers.
Introduction
How to Use This Book
Historical Background
Paper 1
Paper 2
Paper 3
Paper 4
Paper 5
Epilogue
Appendix 1: Mathematical Principles
Appendix 2: Electrical Principles and Circuit Elements
Appendix 3: Electronic Circuits
Appendix 4: Derivations of Rates for the H&H Equations
Appendix 5: Numerical Methods for the H&H Equations
References
Index
Indira M. Raman and David L. Ferster are professors in the Department of Neurobiology at Northwestern University. They are both fellows of the American Academy of Arts and Sciences.
"This wonderful and welcome book on five must-know landmark papers will appeal to anyone interested in biophysics, physiology, neuroscience, biology, applied math, or medicine. With this guide, Raman and Ferster have done a great service to the scientific community."
– Bertil Hille, University of Washington
"Raman and Ferster have succeeded brilliantly with this book, which puts Hodgkin and Huxley's famous work in historical context, explains it in modern terms, and shows how it pointed the way to the modern picture of how nerve signaling works. The annotations bring the beauty of the original experiments into sharp focus and will be a boon to students as well as their teachers."
– Denis Baylor, Stanford University
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