376 pages, 300 colour illustrations
Cell division is a central biological process: it yields the cells required for development and growth, and supplies the replacement cells to repair and maintain old or damaged tissue. But how does this cell division occur? How is it regulated? And what are the consequences when regulation fails?
The second edition of The Cell Cycle: Principles of Control provides an engaging insight into the process of cell division, bringing to the student a much-needed synthesis of a subject entering a period of unprecedented growth as an understanding of the molecular mechanisms underlying cell division are revealed.
The book gives the student a complete overview of the process of cell division – from chromosome duplication through mitosis, cytokinesis, and meiosis – before exploring how cell proliferation is controlled, and how the cell cycle responds to DNA damage. Finally, The Cell Cycle: Principles of Control examines the intrinsic relationship between the cell cycle and cancer, and how a detailed understanding of the cell cycle may lead to new specific therapies to treat the disease.
New to this edition:
- Updated description of recent advances in the field
- Enhanced description of methodological and quantitative aspects of the subject, linked to the concepts being described
- New Experimental Approach Panels in the book describe some of the key technical approaches to research problems in the subject
- Journal Clubs offer suggested research papers and discussion questions linked to topics in The Cell Cycle: Principles of Control
- Increased and updated coverage of stem cell biology and systems biology
"I have enjoyed reading this textbook cover to cover. I have learned new things from chapters that lie outside of my own specialisation of chromosome duplication, and have made interesting new connections. As a University teacher and researcher, I can strongly recommend David Morgan's textbook to students with a background in molecular biology who are interested in the regulation of the eukaryotic cell cycle."
– Torsten Krude in BioEssays, June 2007
"This is an extremely useful book, which can be used in undergraduate (for an advanced course) and graduate teaching, and as a reference book for researchers in the field. The book will remain an essential source of information for curious students and scientists for some time."
– Nature Cell Biology, June 2007
"An excellent reference book for cell biology undergraduates with an interest in the cell cycle and the related field of cancer research. It would also make a useful reference book for any post-graduate student in a cell-cycle laboratory."
– THES Textbooks Guide, February 2007
1: The Cell Cycle
2: Model Organisms in Cell Cycle Analysis
3: The Cell-Cycle Control System
4: Chromosome Duplication
5: Early Mitosis: Preparing for Chromosome Segregation
6: Assembly of the Mitotic Spindle
7: The Completion of Mitosis
10: Control of Cell Proliferation and Growth
11: Cell-Cycle Respomses to DNA Damage
12: The Cell Cycle in Cancer
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David Morgan is a Professor in the Departments of Physiology and Biochemistry & Biophysics at the University of California, San Francisco, where he is a leading researcher on the mechanisms of cell cycle control. He has received awards for his teaching of cardiovascular physiology, cell biology, and biochemistry.